Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1014468..1015087 Replicon chromosome
Accession NZ_CP023578
Organism Mycobacterium tuberculosis strain LE486

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag CP434_RS04950 Protein ID WP_003404726.1
Coordinates 1014653..1015087 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag CP434_RS04945 Protein ID WP_003898641.1
Coordinates 1014468..1014647 (+) Length 60 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP434_RS04935 1009941..1011521 + 1581 WP_003909313.1 serine hydrolase -
CP434_RS04940 1011518..1013911 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
CP434_RS21730 1014184..1014342 + 159 WP_003404720.1 hypothetical protein -
CP434_RS04945 1014468..1014647 + 180 WP_003898641.1 antitoxin Antitoxin
CP434_RS04950 1014653..1015087 + 435 WP_003404726.1 SRPBCC family protein Toxin
CP434_RS04955 1015185..1015958 + 774 WP_003404735.1 VOC family protein -
CP434_RS04960 1016023..1016472 + 450 WP_003404738.1 hypothetical protein -
CP434_RS04965 1016607..1016837 - 231 WP_003898642.1 hypothetical protein -
CP434_RS04970 1017004..1018512 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
CP434_RS04975 1018514..1019752 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-142)

Antitoxin

(4-50)


Sequences


Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T81985 WP_003404726.1 NZ_CP023578:1014653-1015087 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T81985 NZ_CP023578:1014653-1015087 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT81985 WP_003898641.1 NZ_CP023578:1014468-1014647 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT81985 NZ_CP023578:1014468-1014647 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References