81968

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 363178..363704 Replicon chromosome
Accession NZ_CP023578
Organism Mycobacterium tuberculosis strain LE486

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag CP434_RS01610 Protein ID WP_003401560.1
Coordinates 363402..363704 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag CP434_RS01605 Protein ID WP_003401555.1
Coordinates 363178..363405 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP434_RS01590 358871..359674 - 804 WP_003401540.1 hypothetical protein -
CP434_RS01595 359684..361081 - 1398 WP_003401544.1 sulfatase -
CP434_RS01600 361260..363035 + 1776 WP_031675832.1 PE family protein -
CP434_RS01605 363178..363405 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family Antitoxin
CP434_RS01610 363402..363704 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
CP434_RS01615 363752..363973 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
CP434_RS01620 363970..364395 + 426 WP_003401566.1 PIN domain nuclease -
CP434_RS01625 364531..365163 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
CP434_RS01630 365160..366068 + 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(6-41)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T81968 WP_003401560.1 NZ_CP023578:363402-363704 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T81968 NZ_CP023578:363402-363704 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT81968 WP_003401555.1 NZ_CP023578:363178-363405 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT81968 NZ_CP023578:363178-363405 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4F8T1

References