Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2203471..2204015 Replicon chromosome
Accession NZ_CP023576
Organism Mycobacterium tuberculosis strain CSV10399

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag CP432_RS10635 Protein ID WP_003409896.1
Coordinates 2203471..2203767 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag CP432_RS10640 Protein ID WP_003409899.1
Coordinates 2203764..2204015 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP432_RS10580 2198504..2198854 - 351 WP_003899096.1 hypothetical protein -
CP432_RS10585 2198865..2199767 - 903 WP_003899097.1 hypothetical protein -
CP432_RS10590 2199788..2199979 - 192 WP_003409876.1 hypothetical protein -
CP432_RS10595 2199980..2200276 - 297 WP_003409877.1 hypothetical protein -
CP432_RS10600 2200516..2200731 + 216 WP_003409878.1 antitoxin -
CP432_RS10605 2200728..2201039 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
CP432_RS21825 2201013..2201534 - 522 WP_003904745.1 hypothetical protein -
CP432_RS10615 2201509..2201886 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
CP432_RS10620 2201928..2202377 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
CP432_RS10625 2202374..2202919 + 546 WP_003899098.1 SecB-like chaperone -
CP432_RS10630 2202808..2203422 - 615 WP_003901296.1 hypothetical protein -
CP432_RS10635 2203471..2203767 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP432_RS10640 2203764..2204015 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CP432_RS10645 2204002..2204496 + 495 WP_003917554.1 hypothetical protein -
CP432_RS10650 2204656..2205063 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
CP432_RS10655 2205067..2205339 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CP432_RS10660 2205372..2206592 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
CP432_RS10675 2207491..2208288 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T81878 WP_003409896.1 NZ_CP023576:c2203767-2203471 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T81878 NZ_CP023576:c2203767-2203471 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT81878 WP_003409899.1 NZ_CP023576:c2204015-2203764 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT81878 NZ_CP023576:c2204015-2203764 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References