Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1014560..1015179 Replicon chromosome
Accession NZ_CP023573
Organism Mycobacterium tuberculosis strain CSV4519

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag CP429_RS04965 Protein ID WP_003404726.1
Coordinates 1014745..1015179 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag CP429_RS04960 Protein ID WP_003898641.1
Coordinates 1014560..1014739 (+) Length 60 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP429_RS04950 1010033..1011613 + 1581 WP_003909313.1 serine hydrolase -
CP429_RS04955 1011610..1014003 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
CP429_RS21740 1014276..1014434 + 159 WP_003404720.1 hypothetical protein -
CP429_RS04960 1014560..1014739 + 180 WP_003898641.1 antitoxin Antitoxin
CP429_RS04965 1014745..1015179 + 435 WP_003404726.1 SRPBCC family protein Toxin
CP429_RS04970 1015277..1016050 + 774 WP_003404735.1 VOC family protein -
CP429_RS04975 1016115..1016564 + 450 WP_003404738.1 hypothetical protein -
CP429_RS04980 1016699..1016929 - 231 WP_003898642.1 hypothetical protein -
CP429_RS04985 1017096..1018604 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
CP429_RS04990 1018606..1019844 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-142)

Antitoxin

(4-50)


Sequences


Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T81681 WP_003404726.1 NZ_CP023573:1014745-1015179 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T81681 NZ_CP023573:1014745-1015179 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT81681 WP_003898641.1 NZ_CP023573:1014560-1014739 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT81681 NZ_CP023573:1014560-1014739 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References