Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4620508..4621115 Replicon chromosome
Accession NZ_CP023569
Organism Enterobacter hormaechei strain BW

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CPT31_RS21940 Protein ID WP_017382585.1
Coordinates 4620930..4621115 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CPT31_RS21935 Protein ID WP_017382586.1
Coordinates 4620508..4620915 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPT31_RS21905 4616354..4617007 + 654 WP_017382590.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
CPT31_RS21910 4617010..4617870 + 861 WP_017382589.1 L-ribulose-5-phosphate 3-epimerase -
CPT31_RS21915 4617864..4618559 + 696 WP_017382588.1 L-ribulose-5-phosphate 4-epimerase -
CPT31_RS21920 4618560..4618847 - 288 Protein_4287 helix-turn-helix domain-containing protein -
CPT31_RS21925 4618854..4619222 + 369 Protein_4288 glycoside hydrolase family 127 protein -
CPT31_RS21930 4619429..4620504 + 1076 Protein_4289 type I restriction enzyme HsdR N-terminal domain-containing protein -
CPT31_RS21935 4620508..4620915 - 408 WP_017382586.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CPT31_RS21940 4620930..4621115 - 186 WP_017382585.1 type II toxin-antitoxin system HicA family toxin Toxin
CPT31_RS21945 4621365..4622903 - 1539 WP_161503939.1 aldehyde dehydrogenase AldB -
CPT31_RS21950 4623070..4623954 + 885 WP_161503940.1 ROK family protein -
CPT31_RS21955 4623958..4625796 - 1839 WP_017382583.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6794.98 Da        Isoelectric Point: 11.4624

>T81660 WP_017382585.1 NZ_CP023569:c4621115-4620930 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTTGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T81660 NZ_CP023569:c4621115-4620930 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGACGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15171.94 Da        Isoelectric Point: 4.3197

>AT81660 WP_017382586.1 NZ_CP023569:c4620915-4620508 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEAFPLPGNVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPR

Download         Length: 408 bp

>AT81660 NZ_CP023569:c4620915-4620508 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCCGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGACGCTTTTCAGGATGCACGTGATGCGCTCACGGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTTCCTCTCCCGGGTAATGTCGAAGTGCACCTTGAAAATCAACCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAATTCGACGGCAGAGCCGAACGCATCAACATCACGATGCCTCGACGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References