Detailed information of TA system TA081657

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 3555314..3556040
• Replicon: chromosome
• Accession: NZ_CP023569
• Organism: Enterobacter hormaechei strain BW

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: CPT31_RS16775
• Protein ID: WP_072035667.1
• Coordinates: 3555711..3556040 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CPT31_RS16770
• Protein ID: WP_042893201.1
• Coordinates: 3555314..3555673 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPT31_RS16720	3550810..3551217	+	408	WP_042893215.1	hypothetical protein	-
CPT31_RS16725	3551290..3551517	+	228	WP_042893214.1	hypothetical protein	-
CPT31_RS16730	3551598..3551762	+	165	WP_154816236.1	hypothetical protein	-
CPT31_RS16735	3551820..3552656	+	837	WP_045341439.1	hypothetical protein	-
CPT31_RS16740	3552750..3552983	+	234	WP_042893208.1	DUF905 family protein	-
CPT31_RS16745	3553081..3553899	+	819	WP_042893207.1	DUF945 domain-containing protein	-
CPT31_RS16750	3553899..3554153	+	255	WP_072035668.1	hypothetical protein	-
CPT31_RS16755	3554169..3554564	+	396	WP_045341441.1	antirestriction protein	-
CPT31_RS16760	3554576..3555055	+	480	WP_042893205.1	DNA repair protein RadC	-
CPT31_RS16765	3555070..3555291	+	222	WP_042893203.1	DUF987 domain-containing protein	-
CPT31_RS16770	3555314..3555673	+	360	WP_042893201.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CPT31_RS16775	3555711..3556040	+	330	WP_072035667.1	TA system toxin CbtA family protein	Toxin
CPT31_RS16780	3556670..3557908	+	1239	WP_045341443.1	ribokinase	-
CPT31_RS16785	3557976..3558953	+	978	WP_017692843.1	sugar ABC transporter permease	-
CPT31_RS16790	3558953..3559852	+	900	WP_017692842.1	carbohydrate ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3523486..3556040	32554

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (15-115)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12450.17 Da
• Isoelectric Point: 10.5232

>T81657 WP_072035667.1 NZ_CP023569:3555711-3556040 [Enterobacter hormaechei]
MQTLSSHSTRATQPNLSPVKTWQRLLTHLLSQHYGLRLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILRARRSTGLLKTNVK

Nucleotide

• Length: 330 bp

>T81657 NZ_CP023569:3555711-3556040 [Enterobacter hormaechei]
ATGCAAACCTTATCATCACACTCGACACGGGCGACTCAGCCCAATCTGTCACCCGTTAAAACCTGGCAACGGCTGCTGAC
TCATCTGTTATCGCAGCACTATGGCCTGAGGTTGAATGACACACCGTTCAGTAATGAAACCACCATACGAGAACATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAGTACGGGCTTGTCCGTATCGATCGGAAGGGATTT
TCATGGCAAGAACAAACCCCGTATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13412.23 Da
• Isoelectric Point: 5.8752

>AT81657 WP_042893201.1 NZ_CP023569:3555314-3555673 [Enterobacter hormaechei]
MQNTTPVANHDIAEPWWGLKPTVTPCLGARLVQEGNRLHYLADPASITGTFNNEDLRHLDQAFPVLLKQLELMLVSGELT
SRYQHRITLYHNRLTCEADTLGSCGYVCIAIYPDQPEPH

Nucleotide

• Length: 360 bp

>AT81657 NZ_CP023569:3555314-3555673 [Enterobacter hormaechei]
ATGCAGAACACAACACCTGTAGCAAACCATGATATTGCCGAACCCTGGTGGGGACTTAAACCCACCGTCACGCCGTGTCT
TGGCGCACGGCTGGTACAGGAAGGCAACCGGCTGCATTATCTGGCTGACCCGGCAAGTATCACCGGAACATTCAACAATG
AGGATTTACGTCATCTCGACCAGGCGTTTCCGGTATTGCTTAAACAGCTGGAGTTGATGCTCGTTTCCGGTGAGCTCACC
TCCCGCTATCAGCACCGCATCACGCTATATCACAATAGACTGACTTGCGAAGCTGACACACTCGGCTCCTGTGGCTATGT
CTGCATCGCTATTTATCCCGACCAGCCTGAACCCCATTAA