Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2285809..2286548 Replicon chromosome
Accession NZ_CP023569
Organism Enterobacter hormaechei strain BW

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag CPT31_RS10835 Protein ID WP_003857133.1
Coordinates 2285809..2286294 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag CPT31_RS10840 Protein ID WP_003857131.1
Coordinates 2286282..2286548 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPT31_RS10805 2281307..2281921 + 615 WP_080337195.1 NUDIX hydrolase -
CPT31_RS10810 2282105..2282740 - 636 WP_015570517.1 DUF421 domain-containing protein -
CPT31_RS10815 2282750..2283196 - 447 WP_014069654.1 DUF3290 domain-containing protein -
CPT31_RS10820 2283625..2283953 - 329 Protein_2107 helix-turn-helix domain-containing protein -
CPT31_RS10825 2284208..2285173 + 966 WP_045338503.1 hypothetical protein -
CPT31_RS10830 2285189..2285758 + 570 WP_017382346.1 hypothetical protein -
CPT31_RS10835 2285809..2286294 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
CPT31_RS10840 2286282..2286548 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
CPT31_RS10845 2286612..2287541 - 930 WP_026080525.1 LysR family transcriptional regulator -
CPT31_RS10850 2287671..2289059 + 1389 WP_017382343.1 MFS transporter -
CPT31_RS10855 2289082..2290077 - 996 WP_017382342.1 DUF2891 domain-containing protein -
CPT31_RS10860 2290087..2291073 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17572.29 Da        Isoelectric Point: 9.9658

>T81648 WP_003857133.1 NZ_CP023569:c2286294-2285809 [Enterobacter hormaechei]
MGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T81648 NZ_CP023569:c2286294-2285809 [Enterobacter hormaechei]
ATGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACCTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGGAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCAGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT81648 WP_003857131.1 NZ_CP023569:c2286548-2286282 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT81648 NZ_CP023569:c2286548-2286282 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCGGCCATAGAAAAACTGCTG
GCAAGGAAACCACAATGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References