Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1139139..1139759 Replicon chromosome
Accession NZ_CP023569
Organism Enterobacter hormaechei strain BW

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag CPT31_RS05415 Protein ID WP_015571250.1
Coordinates 1139139..1139357 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag CPT31_RS05420 Protein ID WP_006809850.1
Coordinates 1139385..1139759 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPT31_RS05385 1135151..1135411 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
CPT31_RS05390 1135414..1135554 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
CPT31_RS05395 1135551..1136261 - 711 WP_017383207.1 GNAT family N-acetyltransferase -
CPT31_RS05400 1136363..1137823 + 1461 WP_017383208.1 PLP-dependent aminotransferase family protein -
CPT31_RS05405 1137795..1138262 - 468 WP_017383209.1 membrane protein -
CPT31_RS05410 1138379..1138930 - 552 WP_017383210.1 maltose O-acetyltransferase -
CPT31_RS05415 1139139..1139357 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
CPT31_RS05420 1139385..1139759 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
CPT31_RS05425 1140270..1143416 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
CPT31_RS05430 1143439..1144632 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T81647 WP_015571250.1 NZ_CP023569:c1139357-1139139 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T81647 NZ_CP023569:c1139357-1139139 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT81647 WP_006809850.1 NZ_CP023569:c1139759-1139385 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT81647 NZ_CP023569:c1139759-1139385 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References