Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2246173..2247856 Replicon chromosome
Accession NZ_CP023567
Organism Erwinia pyrifoliae strain EpK1/15

Toxin (Protein)


Gene name mosT Uniprot ID E3DHX2
Locus tag CPI84_RS11010 Protein ID WP_012667837.1
Coordinates 2246173..2247090 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID D2T9Q4
Locus tag CPI84_RS11015 Protein ID WP_012667836.1
Coordinates 2247083..2247856 (-) Length 258 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPI84_RS10990 2241983..2242792 - 810 WP_012667841.1 trehalose-phosphatase -
CPI84_RS10995 2243507..2244238 + 732 WP_012667840.1 DUF1275 domain-containing protein -
CPI84_RS11000 2244410..2244829 + 420 WP_012667839.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
CPI84_RS11005 2244832..2246094 + 1263 WP_012667838.1 translesion error-prone DNA polymerase V subunit UmuC -
CPI84_RS11010 2246173..2247090 - 918 WP_012667837.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CPI84_RS11015 2247083..2247856 - 774 WP_012667836.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
CPI84_RS11025 2248341..2249318 - 978 WP_012667835.1 porphobilinogen synthase -
CPI84_RS11030 2249558..2250124 + 567 WP_041473991.1 NAD(P)H-dependent oxidoreductase -
CPI84_RS11035 2250219..2251553 + 1335 WP_012667833.1 cation:proton antiporter -
CPI84_RS11040 2251810..2252172 - 363 WP_014538840.1 PTS galactitol transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34288.50 Da        Isoelectric Point: 4.8381

>T81641 WP_012667837.1 NZ_CP023567:c2247090-2246173 [Erwinia pyrifoliae]
MDKQSPYYRQVALLLSALPVVAAERCFALKGGTAINLFVRDFPRLSVDIDLAYVLLESRDVALPNVRAALMRIAEILQQQ
AGISAVLQTNHSDEMRIVVSSQEAQIKIEVSPVARGTLYPPEERDIVEAVEDEFGFATIQVVSLADLYGGKLCAALDRQH
PRDFYDVKMLLETQGIDRQIFNGFITYLLGHQRPLSEVLNPRWKDISELYANEFNGMTFDAVSLEELNAIPNLMVTALKA
QFTQQDYDFLMSFKSGQPDWSLAPEDQIQHLPAVKWKLQNIGCIPKGKHIQALAKLEAVLAEWIK

Download         Length: 918 bp

>T81641 NZ_CP023567:c2247090-2246173 [Erwinia pyrifoliae]
ATGGATAAGCAATCACCTTATTATCGGCAAGTTGCGTTGCTGCTCAGCGCATTGCCTGTTGTGGCAGCAGAGCGATGCTT
TGCACTAAAAGGTGGAACGGCTATAAACTTGTTTGTCCGTGATTTTCCACGTTTATCGGTTGATATCGATTTGGCTTACG
TTTTGCTGGAAAGCAGAGATGTGGCATTGCCAAATGTTCGGGCTGCTTTGATGCGTATTGCTGAAATACTGCAACAACAG
GCTGGCATTTCGGCGGTGCTACAAACGAATCATTCTGATGAAATGCGCATTGTGGTTTCTTCTCAGGAGGCACAGATAAA
GATAGAAGTTTCGCCTGTTGCGCGAGGCACACTCTATCCCCCAGAAGAACGTGATATTGTTGAAGCGGTAGAGGACGAGT
TCGGTTTCGCTACTATTCAGGTTGTATCGCTTGCCGATCTCTATGGTGGCAAGCTTTGTGCTGCGCTTGACAGGCAACAT
CCCCGTGATTTTTATGACGTCAAAATGCTACTCGAAACGCAAGGCATTGATCGCCAGATCTTTAATGGTTTCATCACCTA
TCTATTGGGACACCAACGCCCATTATCAGAGGTGCTTAATCCCCGCTGGAAAGATATTTCTGAGCTATATGCGAATGAAT
TTAACGGAATGACATTCGATGCGGTTTCTCTGGAAGAACTCAATGCGATACCCAACTTAATGGTTACTGCTCTCAAAGCA
CAATTCACGCAGCAGGATTATGATTTTTTGATGTCTTTCAAAAGTGGTCAACCGGACTGGAGTCTGGCTCCTGAAGATCA
GATTCAGCATCTACCAGCGGTTAAGTGGAAGTTGCAAAATATTGGGTGCATACCAAAAGGTAAGCATATTCAGGCGTTGG
CGAAGCTTGAGGCTGTTCTTGCCGAGTGGATAAAGTAG

Antitoxin


Download         Length: 258 a.a.        Molecular weight: 28877.26 Da        Isoelectric Point: 10.0532

>AT81641 WP_012667836.1 NZ_CP023567:c2247856-2247083 [Erwinia pyrifoliae]
MSSKLNWLLQNTAPGSLVLQSWLTKNGISPSLANKYMHSDWLQKLRAGVYVRSGREPQWNDAVLCLQNQLGISVHLAGLT
SLTWQGRSHYLHLTRQAIWLYVEDKASLPKWFKEFPNVEWLLLSNQKLNMNDEKYLTAVEIKGERLKASVPELAAYEIAN
AVPGSLSFEHAAELFQGLVNLSPRKVEVLLQSSRAVKTNRLYLFLADHYAHAWVTRIDKANIDLGAGKRQIVSGGKLDLK
YQITVPASFVSKGISHG

Download         Length: 774 bp

>AT81641 NZ_CP023567:c2247856-2247083 [Erwinia pyrifoliae]
ATGTCATCAAAACTAAACTGGCTTTTGCAGAACACTGCGCCTGGCTCCTTGGTATTACAGTCCTGGTTGACAAAAAATGG
TATTAGCCCTTCTTTAGCCAATAAGTATATGCATAGTGACTGGTTACAAAAGCTACGTGCCGGTGTATACGTGCGGAGTG
GGCGTGAACCTCAGTGGAACGATGCCGTCTTATGCCTGCAAAATCAGCTGGGGATTTCTGTGCATCTGGCGGGGCTTACC
AGCCTGACCTGGCAGGGACGCTCTCATTATCTTCACTTAACGCGCCAGGCAATTTGGCTTTACGTAGAAGACAAAGCTTC
GTTGCCAAAGTGGTTCAAAGAATTTCCCAATGTCGAGTGGCTTTTACTTTCTAATCAGAAGCTCAATATGAATGACGAAA
AGTATCTGACAGCGGTAGAAATTAAGGGTGAGCGGTTGAAAGCGAGTGTGCCGGAATTAGCTGCTTACGAGATTGCTAAT
GCAGTCCCTGGTTCGCTGTCATTTGAGCACGCTGCGGAGCTGTTTCAGGGGCTGGTAAACCTGAGTCCACGTAAAGTCGA
AGTGTTGTTGCAATCCAGTCGAGCAGTGAAAACTAACCGCCTTTACCTGTTTCTGGCCGATCATTATGCTCATGCATGGG
TTACGCGAATAGATAAAGCCAACATTGATTTAGGGGCCGGGAAACGGCAGATCGTATCTGGTGGCAAGCTGGATCTAAAA
TATCAGATCACTGTTCCAGCGAGTTTTGTTAGCAAAGGGATCTCACATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3DHX2

Antitoxin

Source ID Structure
AlphaFold DB D2T9Q4

References