Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 981020..981554 Replicon chromosome
Accession NZ_CP023567
Organism Erwinia pyrifoliae strain EpK1/15

Toxin (Protein)


Gene name relE Uniprot ID D2T5B9
Locus tag CPI84_RS04705 Protein ID WP_012668982.1
Coordinates 981267..981554 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D2T5C0
Locus tag CPI84_RS04700 Protein ID WP_012668983.1
Coordinates 981020..981262 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPI84_RS04675 976509..977003 + 495 WP_012668988.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
CPI84_RS04680 977000..977335 + 336 WP_012668987.1 hydroxyisourate hydrolase -
CPI84_RS04685 977368..978693 + 1326 WP_012668986.1 purine permease -
CPI84_RS04690 978677..979450 - 774 WP_041474033.1 amidohydrolase -
CPI84_RS04695 979438..980598 - 1161 WP_012668984.1 pyridoxal phosphate-dependent aminotransferase -
CPI84_RS04700 981020..981262 + 243 WP_012668983.1 plasmid stabilization protein Antitoxin
CPI84_RS04705 981267..981554 + 288 WP_012668982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CPI84_RS04715 982003..982617 + 615 WP_012668980.1 methylthioribulose 1-phosphate dehydratase -
CPI84_RS04720 982614..983303 + 690 WP_012668979.1 acireductone synthase -
CPI84_RS04725 983300..983842 + 543 WP_012668978.1 acireductone dioxygenase -
CPI84_RS04730 983894..984925 - 1032 WP_012668977.1 S-methyl-5-thioribose-1-phosphate isomerase -
CPI84_RS04735 985040..986239 + 1200 WP_012668976.1 S-methyl-5-thioribose kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10939.91 Da        Isoelectric Point: 10.7969

>T81639 WP_012668982.1 NZ_CP023567:981267-981554 [Erwinia pyrifoliae]
MIYKVKIRAEALKEWHGLDSAVREQFSKKLKKLRENPHVPSARLTGIAGCYKIKLRSSGFRLVYQVIDEELIIAVVAVGK
RERSQAYKLASERLR

Download         Length: 288 bp

>T81639 NZ_CP023567:981267-981554 [Erwinia pyrifoliae]
TTGATTTATAAGGTTAAAATCAGGGCAGAAGCCCTGAAAGAATGGCATGGTTTGGACAGTGCCGTTCGGGAGCAATTTAG
TAAAAAACTTAAAAAATTGCGTGAAAATCCGCATGTACCTTCAGCCAGGCTAACGGGAATAGCGGGATGTTACAAAATAA
AACTCAGGTCTTCCGGCTTTCGGCTGGTATATCAGGTTATTGATGAAGAGCTGATTATAGCTGTGGTAGCTGTTGGAAAA
AGAGAGCGCAGCCAGGCATATAAACTTGCAAGCGAAAGGTTGCGGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8820.18 Da        Isoelectric Point: 4.0233

>AT81639 WP_012668983.1 NZ_CP023567:981020-981262 [Erwinia pyrifoliae]
MANLILSDTSASVSELKKNPMATVDAGCGFPVAILNRNQPAFYCIPAPLYERMLEVIDDQELVTLVKARENQPLIDLDLD

Download         Length: 243 bp

>AT81639 NZ_CP023567:981020-981262 [Erwinia pyrifoliae]
ATGGCAAATCTCATTCTTAGTGATACCAGTGCAAGCGTAAGCGAGCTTAAAAAGAATCCGATGGCTACAGTTGATGCCGG
TTGCGGCTTTCCTGTAGCGATTCTCAACCGCAATCAGCCCGCTTTCTACTGCATCCCTGCACCACTCTATGAGCGCATGC
TGGAAGTGATAGACGATCAGGAACTGGTCACGCTGGTTAAAGCGCGTGAAAATCAACCTCTGATAGATCTCGATCTGGAC
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D2T5B9

Antitoxin

Source ID Structure
AlphaFold DB D2T5C0

References