Detailed information of TA system TA081638

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 747142..747802
• Replicon: chromosome
• Accession: NZ_CP023567
• Organism: Erwinia pyrifoliae strain EpK1/15

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: D2T6A5
• Locus tag: CPI84_RS03645
• Protein ID: WP_014539414.1
• Coordinates: 747389..747802 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: CPI84_RS03640
• Protein ID: WP_012669171.1
• Coordinates: 747142..747408 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPI84_RS03620	744227..744355	+	129	Protein_695	SDR family oxidoreductase	-
CPI84_RS03625	744449..745057	-	609	WP_012669174.1	HD domain-containing protein	-
CPI84_RS03630	745270..745929	+	660	WP_012669173.1	hemolysin III family protein	-
CPI84_RS03635	745930..746916	-	987	WP_012669172.1	tRNA-modifying protein YgfZ	-
CPI84_RS03640	747142..747408	+	267	WP_012669171.1	FAD assembly factor SdhE	Antitoxin
CPI84_RS03645	747389..747802	+	414	WP_014539414.1	hypothetical protein	Toxin
CPI84_RS03650	747926..748444	-	519	WP_012669169.1	flavodoxin FldB	-
CPI84_RS03655	748490..749443	-	954	WP_012669168.1	DMT family transporter	-
CPI84_RS03660	749719..750612	+	894	WP_014543356.1	site-specific tyrosine recombinase XerD	-
CPI84_RS03665	750658..751362	+	705	WP_012669166.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-130)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16057.13 Da
• Isoelectric Point: 12.3470

>T81638 WP_014539414.1 NZ_CP023567:747389-747802 [Erwinia pyrifoliae]
VVLWQCELRQSKLAQRLSLLLHGAVMLALLLPAWPASAGLVRMLLLVLVLLECIRSRRRIRRRQGDVALLGGHALRWRQR
EWRILSRPWLTRQAILLSLRDAKGERERLWLFADGMADSHWRRLRMQLLNNKEQGNG

Nucleotide

• Length: 414 bp

>T81638 NZ_CP023567:747389-747802 [Erwinia pyrifoliae]
GTGGTCCTGTGGCAATGTGAACTGCGTCAGTCAAAGCTGGCACAGCGGCTTTCGCTGCTGCTGCATGGGGCAGTGATGCT
GGCGCTGCTACTGCCTGCATGGCCCGCCAGCGCTGGCCTGGTACGGATGCTGTTGCTGGTTTTGGTACTGCTGGAGTGCA
TACGCAGCCGGCGGCGCATCCGCCGCCGCCAGGGTGATGTCGCCCTGTTGGGCGGACATGCGCTACGCTGGCGGCAGCGC
GAGTGGCGCATCCTTTCCCGCCCGTGGCTTACCCGGCAGGCGATCCTGCTGTCACTGCGTGATGCCAAAGGGGAGCGTGA
ACGGCTGTGGCTGTTCGCCGACGGCATGGCAGACAGTCACTGGCGTCGGTTACGTATGCAGTTGCTGAACAATAAGGAGC
AGGGGAATGGATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10482.07 Da
• Isoelectric Point: 6.4605

>AT81638 WP_012669171.1 NZ_CP023567:747142-747408 [Erwinia pyrifoliae]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDGDKRLFVRLLESDDPDLFNWLMNHGEPADAELKRMVLLIQQRN
KQRGPVAM

Nucleotide

• Length: 267 bp

>AT81638 NZ_CP023567:747142-747408 [Erwinia pyrifoliae]
ATGGATATTACAAATAAATCACGTATTCACTGGGCATGCCGTCGCGGCATGCGCGAACTGGATATCTCGATCATGCCGTT
TTTTCAGTACGAATTTGACTCGCTGAACGATGGCGATAAGCGTCTGTTTGTCCGCCTGTTAGAGAGCGACGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGAGAGCCGGCAGATGCGGAGCTGAAAAGGATGGTGTTGCTTATCCAGCAGAGAAAT
AAACAACGTGGTCCTGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: D2T6A5