Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 533081..533597 Replicon chromosome
Accession NZ_CP023567
Organism Erwinia pyrifoliae strain EpK1/15

Toxin (Protein)


Gene name relE Uniprot ID D2T7S6
Locus tag CPI84_RS02540 Protein ID WP_012669379.1
Coordinates 533081..533365 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D2T7S5
Locus tag CPI84_RS02545 Protein ID WP_012669378.1
Coordinates 533355..533597 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPI84_RS02510 530285..530686 + 402 WP_012669375.1 helix-turn-helix domain-containing protein -
CPI84_RS02515 530765..531067 + 303 WP_012669374.1 SymE family type I addiction module toxin -
CPI84_RS02520 531127..531579 - 453 WP_012669373.1 SMI1/KNR4 family protein -
CPI84_RS02525 531584..532048 - 465 Protein_481 HNH endonuclease -
CPI84_RS02530 532086..532268 - 183 WP_081441632.1 hypothetical protein -
CPI84_RS19790 532403..532579 + 177 WP_157861020.1 hypothetical protein -
CPI84_RS02540 533081..533365 - 285 WP_012669379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CPI84_RS02545 533355..533597 - 243 WP_012669378.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CPI84_RS02550 533858..534913 - 1056 WP_012669377.1 site-specific tyrosine recombinase XerC -
CPI84_RS02555 535128..537821 - 2694 WP_012669376.1 toprim domain-containing protein -
CPI84_RS02560 537934..538334 + 401 Protein_488 helix-turn-helix domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 485085..548869 63784


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 11123.03 Da        Isoelectric Point: 10.3769

>T81637 WP_012669379.1 NZ_CP023567:c533365-533081 [Erwinia pyrifoliae]
MSYELVFDPRALKEWKKLGATVREQFKKKLAEVLVNPRVESARLREYPDCYKIKLKSSGYRLVYQVQDEQLVVFVVATGK
RERLQVYRDAGKRL

Download         Length: 285 bp

>T81637 NZ_CP023567:c533365-533081 [Erwinia pyrifoliae]
ATGAGCTATGAACTGGTCTTCGATCCCAGAGCCTTAAAAGAGTGGAAAAAACTGGGCGCAACGGTTCGGGAGCAGTTCAA
AAAGAAACTGGCGGAAGTGCTGGTAAACCCGAGGGTGGAATCTGCCAGGTTGAGAGAGTACCCGGACTGCTACAAAATAA
AGCTGAAATCATCGGGTTATCGTCTGGTATATCAGGTTCAGGATGAACAGCTGGTTGTCTTCGTTGTGGCGACAGGAAAA
AGAGAAAGGTTACAGGTGTATCGTGACGCAGGAAAGCGCCTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9070.45 Da        Isoelectric Point: 4.6310

>AT81637 WP_012669378.1 NZ_CP023567:c533597-533355 [Erwinia pyrifoliae]
MATLNVRLDDKLKSKAYAVLDELDVSPTEAVRLLFQYIAENERLPLKTLTVSDEEDALLKTVRERLASPQKGIRVTLDEL

Download         Length: 243 bp

>AT81637 NZ_CP023567:c533597-533355 [Erwinia pyrifoliae]
ATGGCAACATTAAACGTGCGGCTGGATGACAAGCTGAAAAGCAAAGCTTACGCAGTCCTGGATGAACTGGATGTATCACC
AACAGAGGCGGTCCGGCTGCTGTTCCAGTATATAGCGGAAAATGAACGTCTGCCGCTGAAAACGCTGACGGTCAGCGATG
AAGAGGACGCGCTGCTCAAAACGGTGCGCGAAAGGCTGGCATCGCCACAGAAGGGAATAAGGGTCACGCTGGATGAGCTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB D2T7S6


Antitoxin

Source ID Structure
AlphaFold DB D2T7S5

References