Detailed information of TA system TA081636

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 525432..525948
• Replicon: chromosome
• Accession: NZ_CP023567
• Organism: Erwinia pyrifoliae strain EpK1/15

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D2T7S6
• Locus tag: CPI84_RS02490
• Protein ID: WP_012669379.1
• Coordinates: 525432..525716 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D2T7S5
• Locus tag: CPI84_RS02495
• Protein ID: WP_012669378.1
• Coordinates: 525706..525948 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPI84_RS02460	522846..523178	+	333	WP_104945184.1	helix-turn-helix transcriptional regulator	-
CPI84_RS02465	523253..523555	+	303	WP_104945003.1	type I toxin-antitoxin system SymE family toxin	-
CPI84_RS02470	523612..523962	-	351	WP_041474388.1	hypothetical protein	-
CPI84_RS19605	523968..524486	-	519	WP_148666346.1	RHS repeat protein	-
CPI84_RS02480	524437..524619	-	183	WP_081441632.1	hypothetical protein	-
CPI84_RS19785	524754..524930	+	177	WP_157861020.1	hypothetical protein	-
CPI84_RS02490	525432..525716	-	285	WP_012669379.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CPI84_RS02495	525706..525948	-	243	WP_012669378.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CPI84_RS02500	526209..527264	-	1056	WP_012669377.1	site-specific tyrosine recombinase XerC	-
CPI84_RS02505	527479..530172	-	2694	WP_012669376.1	toprim domain-containing protein	-
CPI84_RS02510	530285..530686	+	402	WP_012669375.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	485085..548869	63784

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11123.03 Da
• Isoelectric Point: 10.3769

>T81636 WP_012669379.1 NZ_CP023567:c525716-525432 [Erwinia pyrifoliae]
MSYELVFDPRALKEWKKLGATVREQFKKKLAEVLVNPRVESARLREYPDCYKIKLKSSGYRLVYQVQDEQLVVFVVATGK
RERLQVYRDAGKRL

Nucleotide

• Length: 285 bp

>T81636 NZ_CP023567:c525716-525432 [Erwinia pyrifoliae]
ATGAGCTATGAACTGGTCTTCGATCCCAGAGCCTTAAAAGAGTGGAAAAAACTGGGCGCAACGGTTCGGGAGCAGTTCAA
AAAGAAACTGGCGGAAGTGCTGGTAAACCCGAGGGTGGAATCTGCCAGGTTGAGAGAGTACCCGGACTGCTACAAAATAA
AGCTGAAATCATCGGGTTATCGTCTGGTATATCAGGTTCAGGATGAACAGCTGGTTGTCTTCGTTGTGGCGACAGGAAAA
AGAGAAAGGTTACAGGTGTATCGTGACGCAGGAAAGCGCCTGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9070.45 Da
• Isoelectric Point: 4.6310

>AT81636 WP_012669378.1 NZ_CP023567:c525948-525706 [Erwinia pyrifoliae]
MATLNVRLDDKLKSKAYAVLDELDVSPTEAVRLLFQYIAENERLPLKTLTVSDEEDALLKTVRERLASPQKGIRVTLDEL

Nucleotide

• Length: 243 bp

>AT81636 NZ_CP023567:c525948-525706 [Erwinia pyrifoliae]
ATGGCAACATTAAACGTGCGGCTGGATGACAAGCTGAAAAGCAAAGCTTACGCAGTCCTGGATGAACTGGATGTATCACC
AACAGAGGCGGTCCGGCTGCTGTTCCAGTATATAGCGGAAAATGAACGTCTGCCGCTGAAAACGCTGACGGTCAGCGATG
AAGAGGACGCGCTGCTCAAAACGGTGCGCGAAAGGCTGGCATCGCCACAGAAGGGAATAAGGGTCACGCTGGATGAGCTA
TGA

Structures

Toxin

• AlphaFold DB: D2T7S6

Antitoxin

• AlphaFold DB: D2T7S5