Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 515671..516218 Replicon chromosome
Accession NZ_CP023565
Organism Ligilactobacillus murinus strain CR147

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CPS94_RS02570 Protein ID WP_112195329.1
Coordinates 515946..516218 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CPS94_RS02565 Protein ID WP_112195331.1
Coordinates 515671..515943 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPS94_RS02530 511882..512946 + 1065 WP_162626395.1 Eco57I restriction-modification methylase domain-containing protein -
CPS94_RS02540 513359..513826 + 468 WP_004048046.1 DNA starvation/stationary phase protection protein -
CPS94_RS02545 513964..514332 + 369 WP_004048045.1 ACT domain-containing protein -
CPS94_RS02550 514393..514890 + 498 WP_112195336.1 hypothetical protein -
CPS94_RS02555 514955..515152 + 198 WP_004048043.1 hypothetical protein -
CPS94_RS02560 515184..515366 + 183 WP_112195334.1 hypothetical protein -
CPS94_RS02565 515671..515943 + 273 WP_112195331.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CPS94_RS02570 515946..516218 + 273 WP_112195329.1 type II toxin-antitoxin system YafQ family toxin Toxin
CPS94_RS02575 516533..517495 - 963 WP_004048827.1 IS30 family transposase -
CPS94_RS02580 517546..518394 + 849 WP_112286358.1 GIY-YIG nuclease family protein -
CPS94_RS02585 518536..519468 + 933 WP_112195326.1 site-specific integrase -
CPS94_RS02590 519550..520074 - 525 WP_202863187.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cpsA 498063..543076 45013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10650.37 Da        Isoelectric Point: 8.7743

>T81633 WP_112195329.1 NZ_CP023565:515946-516218 [Ligilactobacillus murinus]
VYKVKFTNKFKKSYKLMKKRGYDMSLLNDIIDALRQGKTLAEKYHNHQLTGEFIGYYECHIKPDWLLIYLVEDDIMTLSL
INTGSHSDLF

Download         Length: 273 bp

>T81633 NZ_CP023565:515946-516218 [Ligilactobacillus murinus]
GTGTATAAAGTCAAATTTACAAATAAATTTAAAAAAAGCTATAAGTTAATGAAAAAACGAGGGTATGATATGTCATTGCT
AAATGATATTATCGATGCGTTAAGGCAAGGGAAAACTCTTGCAGAAAAGTATCATAATCATCAATTAACTGGTGAGTTTA
TTGGATATTATGAATGTCATATTAAACCCGATTGGTTGCTGATATATCTTGTAGAAGATGACATTATGACACTATCGTTG
ATCAATACTGGATCGCATTCAGACTTATTTTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10129.72 Da        Isoelectric Point: 5.6792

>AT81633 WP_112195331.1 NZ_CP023565:515671-515943 [Ligilactobacillus murinus]
MATSPTQIRIDQTVKKEANALFSELGMDMSSAVNMFLRQCILRGGIPFPVELPKYNKETMAAMVEAKRISHDHNVPSYSN
MEDLLKALEE

Download         Length: 273 bp

>AT81633 NZ_CP023565:515671-515943 [Ligilactobacillus murinus]
ATGGCGACAAGTCCAACACAAATTAGGATCGATCAAACAGTAAAAAAGGAAGCGAATGCTCTTTTTTCTGAGTTAGGAAT
GGATATGTCTTCTGCAGTTAATATGTTTTTACGTCAATGCATTTTACGAGGTGGCATACCCTTTCCAGTAGAACTACCGA
AGTATAATAAAGAAACAATGGCTGCAATGGTTGAAGCTAAACGAATTTCACATGACCATAATGTTCCCAGCTATTCAAAC
ATGGAAGACTTGTTGAAAGCTTTGGAGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References