Detailed information of TA system TA081617

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1166263..1166774
• Replicon: chromosome
• Accession: NZ_CP023561
• Organism: Staphylococcus aureus strain TF3198

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: CPC18_RS05915
• Protein ID: WP_148121254.1
• Coordinates: 1166475..1166774 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: CPC18_RS05910
• Protein ID: WP_001058486.1
• Coordinates: 1166263..1166472 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPC18_RS05880	1162225..1163445	-	1221	WP_000270271.1	site-specific integrase	-
CPC18_RS05885	1163459..1164847	-	1389	WP_148121251.1	SAP domain-containing protein	-
CPC18_RS05890	1164874..1165446	-	573	WP_001661454.1	helix-turn-helix domain-containing protein	-
CPC18_RS05895	1165618..1165839	+	222	WP_000560872.1	helix-turn-helix domain-containing protein	-
CPC18_RS05900	1165840..1166112	+	273	WP_148121252.1	pathogenicity island protein	-
CPC18_RS05905	1166124..1166270	+	147	WP_148121253.1	pathogenicity island protein	-
CPC18_RS05910	1166263..1166472	+	210	WP_001058486.1	hypothetical protein	Antitoxin
CPC18_RS05915	1166475..1166774	+	300	WP_148121254.1	DUF1474 family protein	Toxin
CPC18_RS05920	1166849..1168462	+	1614	WP_148121255.1	phage resistance protein	-
CPC18_RS05925	1168633..1169436	+	804	WP_148121256.1	bifunctional DNA primase/polymerase	-
CPC18_RS05930	1169423..1169692	+	270	WP_148121257.1	pathogenicity island protein	-
CPC18_RS05935	1169697..1170338	+	642	WP_148121258.1	pathogenicity island protein	-
CPC18_RS05940	1170912..1171253	+	342	WP_001190614.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	1131812..1176181	44369

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11830.29 Da
• Isoelectric Point: 4.5689

>T81617 WP_148121254.1 NZ_CP023561:1166475-1166774 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHIYFSGSYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDA

Nucleotide

• Length: 300 bp

>T81617 NZ_CP023561:1166475-1166774 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTTATTTTTCTGGTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCATAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT81617 WP_001058486.1 NZ_CP023561:1166263-1166472 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT81617 NZ_CP023561:1166263-1166472 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGTGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA