Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1166263..1166774 Replicon chromosome
Accession NZ_CP023561
Organism Staphylococcus aureus strain TF3198

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag CPC18_RS05915 Protein ID WP_148121254.1
Coordinates 1166475..1166774 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag CPC18_RS05910 Protein ID WP_001058486.1
Coordinates 1166263..1166472 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPC18_RS05880 1162225..1163445 - 1221 WP_000270271.1 site-specific integrase -
CPC18_RS05885 1163459..1164847 - 1389 WP_148121251.1 SAP domain-containing protein -
CPC18_RS05890 1164874..1165446 - 573 WP_001661454.1 helix-turn-helix domain-containing protein -
CPC18_RS05895 1165618..1165839 + 222 WP_000560872.1 helix-turn-helix domain-containing protein -
CPC18_RS05900 1165840..1166112 + 273 WP_148121252.1 pathogenicity island protein -
CPC18_RS05905 1166124..1166270 + 147 WP_148121253.1 pathogenicity island protein -
CPC18_RS05910 1166263..1166472 + 210 WP_001058486.1 hypothetical protein Antitoxin
CPC18_RS05915 1166475..1166774 + 300 WP_148121254.1 DUF1474 family protein Toxin
CPC18_RS05920 1166849..1168462 + 1614 WP_148121255.1 phage resistance protein -
CPC18_RS05925 1168633..1169436 + 804 WP_148121256.1 bifunctional DNA primase/polymerase -
CPC18_RS05930 1169423..1169692 + 270 WP_148121257.1 pathogenicity island protein -
CPC18_RS05935 1169697..1170338 + 642 WP_148121258.1 pathogenicity island protein -
CPC18_RS05940 1170912..1171253 + 342 WP_001190614.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1131812..1176181 44369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11830.29 Da        Isoelectric Point: 4.5689

>T81617 WP_148121254.1 NZ_CP023561:1166475-1166774 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHIYFSGSYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDA

Download         Length: 300 bp

>T81617 NZ_CP023561:1166475-1166774 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTTATTTTTCTGGTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT81617 WP_001058486.1 NZ_CP023561:1166263-1166472 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT81617 NZ_CP023561:1166263-1166472 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGTGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References