Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1149592..1150069 Replicon chromosome
Accession NZ_CP023561
Organism Staphylococcus aureus strain TF3198

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag CPC18_RS05775 Protein ID WP_000052078.1
Coordinates 1149592..1149780 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CPC18_RS05780 Protein ID WP_001059690.1
Coordinates 1149809..1150069 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPC18_RS05745 1145632..1146102 + 471 WP_000824472.1 hypothetical protein -
CPC18_RS05750 1146443..1147129 + 687 WP_001548082.1 thermonuclease family protein -
CPC18_RS05755 1147486..1147686 + 201 WP_001059082.1 cold-shock protein -
CPC18_RS05760 1148183..1148401 - 219 WP_000005886.1 hypothetical protein -
CPC18_RS05765 1148463..1148747 - 285 WP_001004395.1 hypothetical protein -
CPC18_RS05770 1148835..1149404 - 570 WP_001106654.1 hypothetical protein -
CPC18_RS05775 1149592..1149780 - 189 WP_000052078.1 hypothetical protein Toxin
CPC18_RS05780 1149809..1150069 - 261 WP_001059690.1 hypothetical protein Antitoxin
CPC18_RS05785 1150410..1150613 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CPC18_RS05790 1150610..1150846 - 237 WP_000368687.1 hypothetical protein -
CPC18_RS05795 1151071..1151652 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CPC18_RS05800 1151725..1152342 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CPC18_RS05805 1152497..1152991 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CPC18_RS05810 1153390..1153812 - 423 WP_148121250.1 organic hydroperoxide resistance protein -
CPC18_RS05815 1153960..1154676 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1131812..1176181 44369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T81616 WP_000052078.1 NZ_CP023561:c1149780-1149592 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T81616 NZ_CP023561:c1149780-1149592 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT81616 WP_001059690.1 NZ_CP023561:c1150069-1149809 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT81616 NZ_CP023561:c1150069-1149809 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References