Detailed information of TA system TA081612

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1598449..1599080
• Replicon: chromosome
• Accession: NZ_CP023559
• Organism: Salinicola tamaricis strain F01

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CN538_RS07410
• Protein ID: WP_106419020.1
• Coordinates: 1598449..1598631 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CN538_RS07415
• Protein ID: WP_106419021.1
• Coordinates: 1598670..1599080 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CN538_RS19815	1595380..1596054	+	675	WP_129591320.1	hypothetical protein	-
CN538_RS07405	1596329..1597725	-	1397	Protein_1492	GntP family permease	-
CN538_RS07410	1598449..1598631	+	183	WP_106419020.1	type II toxin-antitoxin system HicA family toxin	Toxin
CN538_RS07415	1598670..1599080	+	411	WP_106419021.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CN538_RS07420	1599322..1599747	+	426	WP_106419022.1	hotdog fold thioesterase	-
CN538_RS07425	1599772..1601505	-	1734	WP_106420579.1	AMP-binding protein	-
CN538_RS07430	1601566..1602756	-	1191	WP_106419023.1	acetyl-CoA C-acyltransferase	-
CN538_RS07435	1602802..1603572	-	771	WP_106419024.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1576415..1605337	28922

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.87 Da
• Isoelectric Point: 11.0703

>T81612 WP_106419020.1 NZ_CP023559:1598449-1598631 [Salinicola tamaricis]
VKSRDLIKELEADGWVLDRVRGSHHVFKHPTKPGAVPVPHPKKDMKIGTVNAIRKQAGLK

Nucleotide

• Length: 183 bp

>T81612 NZ_CP023559:1598449-1598631 [Salinicola tamaricis]
GTGAAAAGCAGAGACCTGATCAAGGAGTTGGAAGCCGATGGCTGGGTACTGGACCGCGTCAGAGGTAGCCACCACGTCTT
CAAACACCCAACGAAGCCAGGAGCCGTGCCGGTTCCTCACCCCAAGAAGGACATGAAGATCGGCACGGTCAACGCCATCA
GGAAACAAGCCGGGCTCAAGTAG

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14892.80 Da
• Isoelectric Point: 4.9214

>AT81612 WP_106419021.1 NZ_CP023559:1598670-1599080 [Salinicola tamaricis]
MQYPIAIEWGDDTHATGIVFPDIPGAITAGDSVAHAYEMAVEVAHIQLEELVSAGQPIPKPGSIEQHRQNPDFEGWGWGL
IEIDVTPYLGKTEKVNVTLPGTLVKRIDDYVSLHGIKSRSAFLASAALHELEHRSR

Nucleotide

• Length: 411 bp

>AT81612 NZ_CP023559:1598670-1599080 [Salinicola tamaricis]
ATGCAATATCCGATCGCCATCGAGTGGGGCGACGACACCCACGCAACCGGTATCGTCTTCCCCGACATTCCCGGTGCCAT
CACCGCCGGAGACAGCGTCGCTCACGCCTACGAAATGGCGGTGGAGGTCGCCCATATCCAGCTCGAGGAGCTGGTCAGCG
CCGGCCAGCCGATCCCCAAGCCGGGCAGCATCGAGCAGCACCGCCAAAACCCCGACTTCGAGGGCTGGGGCTGGGGGCTG
ATCGAGATCGACGTCACGCCCTACCTGGGCAAGACCGAAAAGGTCAACGTCACCCTGCCCGGAACGCTGGTCAAGCGAAT
CGACGACTATGTCAGCCTCCACGGCATCAAGAGCCGTTCGGCCTTTCTGGCGTCCGCCGCGCTCCACGAGCTGGAGCATC
GCTCCCGCTGA