Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1417755..1418405 Replicon chromosome
Accession NZ_CP023558
Organism Pseudoalteromonas marina strain ECSMB14103

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CPA52_RS06550 Protein ID WP_039037846.1
Coordinates 1418226..1418405 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CPA52_RS06545 Protein ID WP_039037847.1
Coordinates 1417755..1418171 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPA52_RS06520 1412764..1413177 + 414 WP_039037851.1 hypothetical protein -
CPA52_RS06525 1413187..1413786 + 600 WP_039037850.1 hypothetical protein -
CPA52_RS06530 1413860..1414144 + 285 WP_039037849.1 hypothetical protein -
CPA52_RS06535 1414145..1416706 + 2562 WP_039037848.1 replication endonuclease -
CPA52_RS06540 1417303..1417716 + 414 WP_052242897.1 KilA-N domain-containing protein -
CPA52_RS06545 1417755..1418171 - 417 WP_039037847.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CPA52_RS06550 1418226..1418405 - 180 WP_039037846.1 type II toxin-antitoxin system HicA family toxin Toxin
CPA52_RS06555 1418588..1418938 + 351 WP_039037845.1 hypothetical protein -
CPA52_RS06560 1418935..1419180 - 246 WP_039037844.1 ogr/Delta-like zinc finger family protein -
CPA52_RS06565 1419343..1419768 + 426 WP_052242896.1 SH3 domain-containing protein -
CPA52_RS06570 1420193..1420435 + 243 Protein_1247 hypothetical protein -
CPA52_RS06575 1420771..1421226 - 456 WP_039037843.1 hypothetical protein -
CPA52_RS06580 1421226..1421552 - 327 WP_008135639.1 hypothetical protein -
CPA52_RS06585 1421549..1422616 - 1068 WP_039037842.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6664.73 Da        Isoelectric Point: 10.5730

>T81611 WP_039037846.1 NZ_CP023558:c1418405-1418226 [Pseudoalteromonas marina]
VNSKDLIKQLEEAGWQEVRVKGSHHHFRHPNHTNLITVPHPKKDLGKGLVVKILKDAGL

Download         Length: 180 bp

>T81611 NZ_CP023558:c1418405-1418226 [Pseudoalteromonas marina]
GTGAATAGCAAGGATTTAATCAAACAGCTAGAAGAGGCGGGTTGGCAAGAAGTACGAGTGAAAGGCAGTCATCATCACTT
TAGGCATCCAAACCATACCAACCTGATTACCGTTCCCCACCCTAAGAAAGATTTAGGCAAAGGATTGGTAGTAAAAATAC
TGAAAGATGCGGGGCTTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15211.17 Da        Isoelectric Point: 4.4665

>AT81611 WP_039037847.1 NZ_CP023558:c1418171-1417755 [Pseudoalteromonas marina]
MLYPIAIEKGTETEAFGVVFPDVQGCYSAGDSFEQALLNAKDALETHLELLAEDGILPPQSSNINDHVNNPEFSGWVWAL
IDIDLEPYLGKAGKINVTLPNLLTKQIDDLVKAHPHYKSRSNFLQLAAQHEIQGISAR

Download         Length: 417 bp

>AT81611 NZ_CP023558:c1418171-1417755 [Pseudoalteromonas marina]
ATGTTATATCCAATCGCAATTGAAAAAGGCACAGAAACTGAAGCATTTGGTGTGGTGTTTCCTGATGTGCAAGGCTGTTA
TAGTGCCGGTGACTCATTCGAGCAAGCACTATTAAACGCTAAAGACGCACTAGAAACTCATTTAGAGTTATTAGCCGAAG
ACGGTATTTTACCGCCACAATCAAGCAATATTAACGATCACGTAAATAACCCTGAATTTTCAGGCTGGGTGTGGGCGTTG
ATTGATATTGACCTTGAACCCTACTTAGGCAAAGCAGGTAAAATTAACGTTACCTTGCCTAACCTACTTACTAAACAAAT
TGATGATTTAGTAAAAGCACATCCACACTATAAAAGCCGTTCAAACTTTTTACAGTTAGCGGCGCAGCATGAAATACAGG
GTATTTCAGCACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References