Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3492949..3493574 Replicon chromosome
Accession NZ_CP023541
Organism Escherichia coli O104:H21 str. CFSAN002236 strain ATCC BAA-178

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag CR208_RS17005 Protein ID WP_000911329.1
Coordinates 3492949..3493347 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag CR208_RS17010 Protein ID WP_000450524.1
Coordinates 3493347..3493574 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR208_RS16985 3488856..3489056 + 201 WP_000383836.1 YpfN family protein -
CR208_RS16990 3489137..3489835 - 699 WP_000679812.1 esterase -
CR208_RS16995 3489909..3491924 - 2016 WP_000829335.1 tRNA cytosine(34) acetyltransferase TmcA -
CR208_RS17000 3491939..3492802 - 864 WP_001267507.1 neutral zinc metallopeptidase -
CR208_RS17005 3492949..3493347 - 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
CR208_RS17010 3493347..3493574 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
CR208_RS17015 3493730..3494443 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
CR208_RS17020 3494656..3495690 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
CR208_RS17025 3495707..3496585 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
CR208_RS17030 3496731..3497303 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
CR208_RS17035 3497303..3497773 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-125)

Antitoxin

(7-52)


Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T81599 WP_000911329.1 NZ_CP023541:c3493347-3492949 [Escherichia coli O104:H21 str. CFSAN002236]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T81599 NZ_CP023541:c3493347-3492949 [Escherichia coli O104:H21 str. CFSAN002236]
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT81599 WP_000450524.1 NZ_CP023541:c3493574-3493347 [Escherichia coli O104:H21 str. CFSAN002236]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT81599 NZ_CP023541:c3493574-3493347 [Escherichia coli O104:H21 str. CFSAN002236]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84


Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References