Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 449891..450426 Replicon chromosome
Accession NZ_CP023539
Organism Staphylococcus lugdunensis strain FDAARGOS_377

Toxin (Protein)


Gene name TscT Uniprot ID C5QLS6
Locus tag CPG32_RS02270 Protein ID WP_002445368.1
Coordinates 450103..450426 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID C5QLS5
Locus tag CPG32_RS02265 Protein ID WP_001058489.1
Coordinates 449891..450100 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPG32_RS02230 445147..445431 + 285 WP_002461410.1 co-chaperone GroES -
CPG32_RS02235 445491..447113 + 1623 WP_002461409.1 chaperonin GroEL -
CPG32_RS02240 447182..448354 - 1173 WP_002492309.1 site-specific integrase -
CPG32_RS02245 448368..449042 - 675 WP_002445345.1 helix-turn-helix transcriptional regulator -
CPG32_RS02250 449215..449433 + 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
CPG32_RS02255 449438..449755 + 318 WP_002445364.1 helix-turn-helix domain-containing protein -
CPG32_RS02260 449752..449898 + 147 WP_002445365.1 hypothetical protein -
CPG32_RS02265 449891..450100 + 210 WP_001058489.1 hypothetical protein Antitoxin
CPG32_RS02270 450103..450426 + 324 WP_002445368.1 DUF1474 family protein Toxin
CPG32_RS02275 450490..451359 + 870 WP_002445370.1 primase alpha helix C-terminal domain-containing protein -
CPG32_RS02280 451373..453082 + 1710 WP_002445371.1 DUF927 domain-containing protein -
CPG32_RS02285 453430..453795 + 366 WP_002445372.1 hypothetical protein -
CPG32_RS02290 453809..454450 + 642 WP_002492310.1 pathogenicity island protein -
CPG32_RS02295 454738..455082 + 345 WP_002445374.1 hypothetical protein -
CPG32_RS02300 455096..455329 + 234 WP_002492317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 445147..458319 13172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 13107.51 Da        Isoelectric Point: 4.8571

>T81579 WP_002445368.1 NZ_CP023539:450103-450426 [Staphylococcus lugdunensis]
MNWEIKNLFSDLKLLKDSFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIQ
KFHELEKASSENFGEESDDAQKLKITE

Download         Length: 324 bp

>T81579 NZ_CP023539:450103-450426 [Staphylococcus lugdunensis]
ATGAATTGGGAAATTAAAAATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATTTTGAGGAGTTATATCCACATGAACCAAATCATAACTTAAATAAAGATGAATTAATTAGAGAGGGTTTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAACAGTTCGATAAAATTATACAA
AAGTTTCATGAATTAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCACAAAAATTAAAAATCACAGA
GTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8225.24 Da        Isoelectric Point: 4.2820

>AT81579 WP_001058489.1 NZ_CP023539:449891-450100 [Staphylococcus lugdunensis]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT81579 NZ_CP023539:449891-450100 [Staphylococcus lugdunensis]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A853V601

References