Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 628554..630300 Replicon chromosome
Accession NZ_CP023538
Organism Ralstonia pickettii strain FDAARGOS_410

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CO705_RS18640 Protein ID WP_096746119.1
Coordinates 629395..630300 (-) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CO705_RS18635 Protein ID WP_096746118.1
Coordinates 628554..629381 (-) Length 276 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO705_RS18615 623702..625183 - 1482 WP_096746114.1 aldehyde dehydrogenase -
CO705_RS18620 625192..625995 - 804 WP_096746115.1 aspartate dehydrogenase -
CO705_RS18625 626028..627755 - 1728 WP_096746116.1 thiamine pyrophosphate-binding protein -
CO705_RS18630 627748..628551 - 804 WP_096746117.1 SDR family oxidoreductase -
CO705_RS18635 628554..629381 - 828 WP_096746118.1 IclR family transcriptional regulator Antitoxin
CO705_RS18640 629395..630300 - 906 WP_096746119.1 alpha/beta hydrolase Toxin
CO705_RS18645 630305..630841 - 537 WP_063394580.1 cupin domain-containing protein -
CO705_RS18650 630892..631665 - 774 WP_063394581.1 SDR family oxidoreductase -
CO705_RS18655 631658..632725 - 1068 WP_096746120.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
CO705_RS18660 632807..633109 - 303 WP_063394583.1 hypothetical protein -
CO705_RS18665 633331..633792 - 462 WP_063394584.1 GNAT family N-acetyltransferase -
CO705_RS18670 634115..634354 - 240 WP_063394585.1 DUF2798 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-288)

Antitoxin

Transcription regulator IclR, C-terminal

(137-258)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 32031.20 Da        Isoelectric Point: 6.8317

>T81576 WP_096746119.1 NZ_CP023538:c630300-629395 [Ralstonia pickettii]
MSAQAVMSSRPFRVADALAVLEAEFAERSVTINAQGDRIGYRQWGGRGPVVVLLHGISSSAASWLPCAQVLSQTMRVFAW
DAPGYGRSTPLEQAEPRAADYAQRLQAWLGALQVKPEVIVGHSLGALMAAAYVAHAPEALQPGCVLLLNPAQGYGQPGHE
DQSRSVRAQRLATLDRLGIEGMAESRHAHLLRPDAGSEARAWVRWNMLRLNDGGYRQAVAMLSGDDIGGYLRKRAASTPA
RVACGDVDGITPPQGCEALADAFGLPFARVADAGHASYIDAPDAVAGWIAQAAFSSFQNAY

Download         Length: 906 bp

>T81576 NZ_CP023538:c630300-629395 [Ralstonia pickettii]
ATGAGCGCGCAGGCTGTCATGTCTTCCCGTCCGTTTCGCGTGGCCGATGCACTGGCCGTGCTCGAGGCCGAGTTTGCCGA
ACGCAGCGTCACGATCAACGCCCAGGGCGATCGCATCGGCTATCGGCAGTGGGGCGGTCGCGGGCCGGTGGTGGTGCTGT
TGCACGGCATCAGCTCCAGCGCCGCGTCGTGGCTGCCTTGCGCGCAGGTTCTCTCGCAAACCATGCGCGTGTTCGCGTGG
GATGCGCCGGGCTATGGCCGATCCACGCCGCTCGAACAAGCCGAGCCGCGCGCTGCCGATTACGCGCAACGCTTGCAGGC
ATGGCTGGGCGCGCTGCAGGTGAAGCCGGAGGTGATCGTCGGACATTCGCTGGGCGCGCTGATGGCTGCGGCCTATGTGG
CCCACGCGCCGGAAGCGCTGCAACCCGGCTGCGTGCTGCTGCTGAACCCCGCGCAGGGTTACGGGCAGCCCGGTCACGAA
GACCAGTCCCGCAGTGTGCGGGCCCAGCGCCTTGCCACGCTCGACCGGCTTGGCATCGAGGGCATGGCGGAATCGCGCCA
CGCGCATCTGCTGCGCCCGGATGCCGGCAGCGAAGCGCGCGCCTGGGTGCGCTGGAACATGCTGCGCCTGAACGACGGCG
GTTACCGCCAGGCCGTGGCCATGCTCAGCGGCGACGACATCGGCGGGTATCTGCGCAAGCGCGCGGCTTCAACGCCGGCC
CGCGTGGCCTGTGGCGATGTCGACGGCATCACGCCGCCGCAGGGCTGCGAAGCGTTGGCCGACGCCTTCGGCCTGCCTTT
CGCGCGGGTGGCCGACGCCGGGCACGCGTCGTACATCGATGCGCCGGATGCCGTTGCCGGCTGGATCGCACAAGCCGCTT
TCTCCTCATTCCAAAACGCCTACTAA

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30588.29 Da        Isoelectric Point: 5.4605

>AT81576 WP_096746118.1 NZ_CP023538:c629381-628554 [Ralstonia pickettii]
MSNDLIPEDVQEKYIVPGLERGLRLLCEFSHKDRVLSAPELARRLKVPRSTVFRLLTTLEVMGFIERVDGGRDFRLGMAV
LRLGFEYLASLELTELGRPLLDRLRDDIHYPCNLVVRDGRSIVYVAKSVAPTPFTSSVNVGTRLPAHATVLGRVLLADLS
LAELRQLYPEPQLEAFTANTPRTVEDLFEMVQRDREHGYVLEEGFFEANISTIAAPVLDRAGKIVAALGTTIPSPRIDPA
QLDSMIDKVRAAAGELSYLLDYRPASGKVVNLFGE

Download         Length: 828 bp

>AT81576 NZ_CP023538:c629381-628554 [Ralstonia pickettii]
ATGAGCAACGACCTCATTCCCGAAGACGTGCAGGAAAAGTACATCGTGCCCGGGCTCGAACGCGGCCTGCGCCTGCTGTG
CGAGTTCAGCCACAAAGACCGCGTGCTGTCTGCGCCGGAACTGGCGCGCCGGCTGAAGGTGCCGCGCTCCACGGTGTTCC
GCCTGCTGACCACGCTCGAGGTGATGGGCTTCATCGAGCGCGTGGACGGCGGCCGGGATTTCCGCCTCGGCATGGCCGTG
CTGCGCCTCGGGTTCGAATATCTCGCCTCGCTCGAGTTGACCGAACTCGGCCGTCCGCTGCTCGACCGCCTGCGCGACGA
CATTCACTATCCGTGCAACCTCGTCGTGCGCGATGGCCGCTCGATCGTCTACGTGGCGAAATCGGTGGCGCCGACGCCGT
TCACGAGCTCGGTCAACGTCGGTACCCGCCTGCCCGCGCATGCCACGGTGCTGGGGCGCGTGCTGCTGGCCGACCTGTCG
CTGGCCGAGCTGCGTCAGCTGTATCCGGAGCCGCAGCTGGAGGCATTCACCGCCAACACGCCGCGCACCGTGGAAGACCT
GTTCGAGATGGTGCAGCGCGACCGCGAACACGGCTACGTGCTCGAAGAGGGCTTCTTCGAGGCGAACATCTCGACGATCG
CGGCGCCGGTGCTCGACCGCGCCGGCAAGATCGTCGCCGCACTCGGTACGACGATCCCGTCGCCGCGCATCGACCCCGCG
CAGCTCGATTCCATGATCGACAAGGTGCGCGCTGCCGCAGGCGAGCTCTCTTACCTGCTCGACTACCGCCCGGCCAGCGG
CAAGGTCGTCAACCTGTTCGGGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References