Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5259506..5260324 Replicon chromosome
Accession NZ_CP023535
Organism Escherichia coli strain FDAARGOS_403

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0Y102
Locus tag CO706_RS28930 Protein ID WP_000771609.1
Coordinates 5259950..5260324 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0Y470
Locus tag CO706_RS28925 Protein ID WP_001285568.1
Coordinates 5259506..5259859 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO706_RS28885 5255691..5256374 + 684 WP_000775510.1 hypothetical protein -
CO706_RS28890 5256390..5256800 + 411 WP_000846716.1 hypothetical protein -
CO706_RS28900 5257021..5257842 + 822 WP_001241709.1 DUF945 domain-containing protein -
CO706_RS28905 5257842..5258087 + 246 WP_001164966.1 hypothetical protein -
CO706_RS28910 5258181..5258654 + 474 WP_000855049.1 antirestriction protein -
CO706_RS28915 5258670..5259146 + 477 WP_001186756.1 RadC family protein -
CO706_RS28920 5259209..5259430 + 222 WP_000692357.1 DUF987 domain-containing protein -
CO706_RS28925 5259506..5259859 + 354 WP_001285568.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
CO706_RS28930 5259950..5260324 + 375 WP_000771609.1 TA system toxin CbtA family protein Toxin
CO706_RS28935 5260321..5260812 + 492 WP_000976860.1 hypothetical protein -
CO706_RS28940 5260824..5261021 + 198 WP_000839270.1 DUF957 domain-containing protein -
CO706_RS28945 5261106..5261948 + 843 WP_001274560.1 DUF4942 domain-containing protein -
CO706_RS28955 5262419..5263357 + 939 WP_000351313.1 glyoxylate/hydroxypyruvate reductase GhrA -
CO706_RS28960 5263412..5264149 + 738 WP_000283664.1 zinc-binding phosphatase -
CO706_RS28965 5264173..5264727 + 555 WP_001001902.1 molecular chaperone YcdY -
CO706_RS28970 5264829..5265320 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14006.09 Da        Isoelectric Point: 7.2652

>T81573 WP_000771609.1 NZ_CP023535:5259950-5260324 [Escherichia coli]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T81573 NZ_CP023535:5259950-5260324 [Escherichia coli]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCATGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13064.82 Da        Isoelectric Point: 5.9541

>AT81573 WP_001285568.1 NZ_CP023535:5259506-5259859 [Escherichia coli]
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK

Download         Length: 354 bp

>AT81573 NZ_CP023535:5259506-5259859 [Escherichia coli]
GTGTCAGACACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y102

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y470

References