Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4466215..4466833 Replicon chromosome
Accession NZ_CP023535
Organism Escherichia coli strain FDAARGOS_403

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CO706_RS24720 Protein ID WP_001291435.1
Coordinates 4466215..4466433 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag CO706_RS24725 Protein ID WP_000344800.1
Coordinates 4466459..4466833 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO706_RS24685 4461505..4462077 + 573 WP_000779826.1 lipoprotein -
CO706_RS24690 4462108..4462419 - 312 WP_000409911.1 MGMT family protein -
CO706_RS24700 4462798..4463151 + 354 WP_000878140.1 DUF1428 domain-containing protein -
CO706_RS24705 4463193..4464743 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
CO706_RS24710 4464907..4465377 - 471 WP_000136192.1 YlaC family protein -
CO706_RS24715 4465493..4466044 - 552 WP_000102564.1 maltose O-acetyltransferase -
CO706_RS24720 4466215..4466433 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
CO706_RS24725 4466459..4466833 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
CO706_RS24730 4467379..4470528 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
CO706_RS24735 4470551..4471744 - 1194 WP_001386618.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T81572 WP_001291435.1 NZ_CP023535:c4466433-4466215 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T81572 NZ_CP023535:c4466433-4466215 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT81572 WP_000344800.1 NZ_CP023535:c4466833-4466459 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT81572 NZ_CP023535:c4466833-4466459 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References