Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3078957..3079758 Replicon chromosome
Accession NZ_CP023535
Organism Escherichia coli strain FDAARGOS_403

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag CO706_RS17655 Protein ID WP_001094437.1
Coordinates 3079381..3079758 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag CO706_RS17650 Protein ID WP_001390338.1
Coordinates 3078957..3079334 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO706_RS17615 3076075..3076233 + 159 WP_001323397.1 DUF905 family protein -
CO706_RS17625 3076388..3077206 + 819 WP_001234716.1 DUF945 domain-containing protein -
CO706_RS29850 3077206..3077379 + 174 WP_001183321.1 hypothetical protein -
CO706_RS17635 3077545..3078018 + 474 WP_001387789.1 antirestriction protein -
CO706_RS17640 3078034..3078510 + 477 WP_001186773.1 RadC family protein -
CO706_RS17645 3078573..3078794 + 222 WP_000692300.1 DUF987 domain-containing protein -
CO706_RS17650 3078957..3079334 + 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CO706_RS17655 3079381..3079758 + 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
CO706_RS17660 3079755..3080243 + 489 WP_000761716.1 hypothetical protein -
CO706_RS17665 3080263..3080460 + 198 WP_000772032.1 DUF957 domain-containing protein -
CO706_RS17670 3080545..3081390 + 846 WP_001274561.1 DUF4942 domain-containing protein -
CO706_RS17685 3082183..3083367 + 1185 WP_001172875.1 sugar efflux transporter -
CO706_RS17690 3083478..3084401 + 924 WP_000535960.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T81565 WP_001094437.1 NZ_CP023535:3079381-3079758 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T81565 NZ_CP023535:3079381-3079758 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT81565 WP_001390338.1 NZ_CP023535:3078957-3079334 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT81565 NZ_CP023535:3078957-3079334 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References