Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3836001..3836802 Replicon chromosome
Accession NZ_CP023531
Organism Escherichia coli strain FDAARGOS_401

Toxin (Protein)


Gene name yeeV Uniprot ID D3GUT5
Locus tag CO703_RS20800 Protein ID WP_001094430.1
Coordinates 3836425..3836802 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D3GUT4
Locus tag CO703_RS20795 Protein ID WP_001285620.1
Coordinates 3836001..3836378 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO703_RS20760 3831206..3832713 - 1508 Protein_3699 group II intron reverse transcriptase/maturase -
CO703_RS20770 3833385..3834124 - 740 Protein_3700 IS3 family transposase -
CO703_RS29335 3834181..3834306 + 126 Protein_3701 DUF945 domain-containing protein -
CO703_RS20780 3834648..3835121 + 474 WP_000855057.1 antirestriction protein -
CO703_RS20785 3835137..3835613 + 477 WP_001387238.1 RadC family protein -
CO703_RS20790 3835700..3835921 + 222 WP_000692350.1 DUF987 domain-containing protein -
CO703_RS20795 3836001..3836378 + 378 WP_001285620.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
CO703_RS20800 3836425..3836802 + 378 WP_001094430.1 TA system toxin CbtA family protein Toxin
CO703_RS20805 3836799..3837287 + 489 WP_000761715.1 hypothetical protein -
CO703_RS20810 3837307..3837504 + 198 WP_000772029.1 DUF957 domain-containing protein -
CO703_RS20815 3837589..3838431 + 843 WP_001290187.1 DUF4942 domain-containing protein -
CO703_RS20825 3839180..3840718 + 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13971.82 Da        Isoelectric Point: 6.8608

>T81538 WP_001094430.1 NZ_CP023531:3836425-3836802 [Escherichia coli]
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T81538 NZ_CP023531:3836425-3836802 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAAGCGAAACAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13698.52 Da        Isoelectric Point: 5.9505

>AT81538 WP_001285620.1 NZ_CP023531:3836001-3836378 [Escherichia coli]
VSDTLPGTTPPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV

Download         Length: 378 bp

>AT81538 NZ_CP023531:3836001-3836378 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGTAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACTGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y6M7

Antitoxin

Source ID Structure
PDB 2INW
AlphaFold DB A0A0E0Y522

References