Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2203912..2204730 Replicon chromosome
Accession NZ_CP023531
Organism Escherichia coli strain FDAARGOS_401

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0Y102
Locus tag CO703_RS12270 Protein ID WP_000771609.1
Coordinates 2203912..2204286 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0Y470
Locus tag CO703_RS12275 Protein ID WP_001285568.1
Coordinates 2204377..2204730 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO703_RS12230 2198916..2199407 - 492 WP_001297187.1 DUF1097 domain-containing protein -
CO703_RS12235 2199509..2200063 - 555 WP_001001902.1 molecular chaperone YcdY -
CO703_RS12240 2200087..2200824 - 738 WP_000283664.1 zinc-binding phosphatase -
CO703_RS12245 2200879..2201817 - 939 WP_000351313.1 glyoxylate/hydroxypyruvate reductase GhrA -
CO703_RS12255 2202288..2203130 - 843 WP_001274560.1 DUF4942 domain-containing protein -
CO703_RS12260 2203215..2203412 - 198 WP_000839270.1 DUF957 domain-containing protein -
CO703_RS12265 2203424..2203915 - 492 WP_000976860.1 hypothetical protein -
CO703_RS12270 2203912..2204286 - 375 WP_000771609.1 TA system toxin CbtA family protein Toxin
CO703_RS12275 2204377..2204730 - 354 WP_001285568.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
CO703_RS12280 2204806..2205027 - 222 WP_000692357.1 DUF987 domain-containing protein -
CO703_RS12285 2205090..2205566 - 477 WP_001186756.1 RadC family protein -
CO703_RS12290 2205582..2206055 - 474 WP_000855049.1 antirestriction protein -
CO703_RS12295 2206149..2206394 - 246 WP_001164966.1 hypothetical protein -
CO703_RS12300 2206394..2207215 - 822 WP_001241709.1 DUF945 domain-containing protein -
CO703_RS12310 2207463..2209075 - 1613 Protein_2174 IS66-like element ISEc43 family transposase -
CO703_RS12315 2209106..2209456 - 351 WP_000624688.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14006.09 Da        Isoelectric Point: 7.2652

>T81533 WP_000771609.1 NZ_CP023531:c2204286-2203912 [Escherichia coli]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T81533 NZ_CP023531:c2204286-2203912 [Escherichia coli]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCATGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13064.82 Da        Isoelectric Point: 5.9541

>AT81533 WP_001285568.1 NZ_CP023531:c2204730-2204377 [Escherichia coli]
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK

Download         Length: 354 bp

>AT81533 NZ_CP023531:c2204730-2204377 [Escherichia coli]
GTGTCAGACACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y102

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y470

References