Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 470623..471248 Replicon chromosome
Accession NZ_CP023531
Organism Escherichia coli strain FDAARGOS_401

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag CO703_RS02885 Protein ID WP_000911329.1
Coordinates 470850..471248 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag CO703_RS02880 Protein ID WP_000450524.1
Coordinates 470623..470850 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO703_RS02855 466425..466895 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
CO703_RS02860 466895..467467 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
CO703_RS02865 467613..468491 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
CO703_RS02870 468508..469542 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
CO703_RS02875 469755..470468 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
CO703_RS02880 470623..470850 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
CO703_RS02885 470850..471248 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
CO703_RS02890 471395..472258 + 864 WP_001267498.1 neutral zinc metallopeptidase -
CO703_RS02895 472273..474288 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
CO703_RS02900 474362..475060 + 699 WP_000679823.1 esterase -
CO703_RS02905 475170..475370 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-125)

Antitoxin

(7-52)


Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T81521 WP_000911329.1 NZ_CP023531:470850-471248 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T81521 NZ_CP023531:470850-471248 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT81521 WP_000450524.1 NZ_CP023531:470623-470850 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT81521 NZ_CP023531:470623-470850 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84


Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References