Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 61646..62301 Replicon plasmid unnamed
Accession NZ_CP023530
Organism Escherichia coli strain FDAARGOS_401

Toxin (Protein)


Gene name vagD Uniprot ID A0A2H3M3N3
Locus tag CO703_RS00405 Protein ID WP_001392130.1
Coordinates 61646..62047 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0E0YAG4
Locus tag CO703_RS00410 Protein ID WP_001261288.1
Coordinates 62071..62301 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO703_RS00360 56784..57068 + 285 WP_001387467.1 ribbon-helix-helix domain-containing protein -
CO703_RS00365 57068..57343 + 276 WP_000421273.1 type II toxin-antitoxin system RelE/ParE family toxin -
CO703_RS00370 57349..57680 + 332 Protein_65 type II toxin-antitoxin system ParD family antitoxin -
CO703_RS00375 57796..57957 + 162 WP_001440647.1 type II toxin-antitoxin system RelE/ParE family toxin -
CO703_RS00380 58080..58205 + 126 WP_032159539.1 hypothetical protein -
CO703_RS00385 58326..59066 + 741 WP_001066951.1 tyrosine-type recombinase/integrase -
CO703_RS00390 59345..60322 - 978 WP_001387465.1 RepB family plasmid replication initiator protein -
CO703_RS00400 61408..61563 + 156 WP_000332512.1 transposase domain-containing protein -
CO703_RS00405 61646..62047 - 402 WP_001392130.1 type II toxin-antitoxin system VapC family toxin Toxin
CO703_RS00410 62071..62301 - 231 WP_001261288.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CO703_RS00415 62896..63114 + 219 WP_000813638.1 type II toxin-antitoxin system antitoxin CcdA -
CO703_RS00420 63116..63421 + 306 WP_001159872.1 type II toxin-antitoxin system toxin CcdB -
CO703_RS00425 63422..64228 + 807 WP_000016961.1 site-specific integrase -
CO703_RS00430 64407..65051 + 645 WP_001144032.1 ParA family protein -
CO703_RS00435 65138..65446 + 309 WP_000030204.1 molecular chaperone GroEL -
CO703_RS00440 65860..66840 + 981 WP_000688504.1 plasmid segregation protein ParM -
CO703_RS00445 66833..67249 + 417 WP_001278815.1 plasmid partitioning/stability family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - aap/aspU / aggD / aggC / aggB / aggA 1..75554 75554


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14647.00 Da        Isoelectric Point: 6.7123

>T81517 WP_001392130.1 NZ_CP023530:c62047-61646 [Escherichia coli]
MLDTNICSFIMREQPAAVIKRLEQAVLRNHRIVVSAITYAEMRFDATGPKASPRHIALVDAFCARLDAILPWDRAAVDAT
TEIKMALRLAETPIGPNNTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 402 bp

>T81517 NZ_CP023530:c62047-61646 [Escherichia coli]
ATGCTCGACACGAATATCTGCTCTTTCATTATGCGTGAACAGCCCGCCGCAGTGATCAAACGTCTGGAGCAGGCGGTGCT
GCGTAACCACCGCATTGTCGTGTCGGCCATCACCTATGCGGAGATGCGTTTCGACGCCACCGGCCCGAAAGCCTCACCGC
GTCATATTGCGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATTCTGCCCTGGGACCGCGCTGCCGTGGACGCCACC
ACGGAGATTAAAATGGCACTGCGGCTGGCCGAGACGCCAATCGGCCCGAACAACACGGCGATTGCCGGGCACGCCATCGC
TGCCGGGGCGATACTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCTGACCTGGTGCTGGAAGACTGGGTGAAGT
AA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8684.76 Da        Isoelectric Point: 4.3654

>AT81517 WP_001261288.1 NZ_CP023530:c62301-62071 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWSSFAALEKADADFMAEREDIVSDEGRFDL

Download         Length: 231 bp

>AT81517 NZ_CP023530:c62301-62071 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCCCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTTGAGATCGTCCGCGAAGGAGACAGCATTATATTGCGCCCGGTCCGGCCGACCTGGAGCTCGTTTGCGGCACTCG
AAAAGGCCGACGCAGACTTTATGGCGGAGCGTGAGGACATTGTCAGCGACGAAGGAAGATTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H3M3N3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0YAG4

References