Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 3760911..3761508 Replicon chromosome
Accession NZ_CP023529
Organism Lelliottia amnigena strain FDAARGOS_395

Toxin (Protein)


Gene name PumA Uniprot ID A0A3S5XVP2
Locus tag CO697_RS18315 Protein ID WP_059179822.1
Coordinates 3761191..3761508 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3S5XWI6
Locus tag CO697_RS18310 Protein ID WP_059179821.1
Coordinates 3760911..3761198 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO697_RS18305 3759283..3760914 + 1632 WP_059179820.1 Na/Pi cotransporter family protein -
CO697_RS18310 3760911..3761198 - 288 WP_059179821.1 putative addiction module antidote protein Antitoxin
CO697_RS18315 3761191..3761508 - 318 WP_059179822.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CO697_RS18320 3761698..3762567 + 870 WP_059179823.1 23S rRNA pseudouridine(2604) synthase RluF -
CO697_RS18325 3762568..3762840 - 273 WP_059179824.1 DUF3811 domain-containing protein -
CO697_RS18330 3762903..3763847 - 945 WP_059179825.1 ketopantoate/pantoate/pantothenate transporter PanS -
CO697_RS18335 3763940..3765289 - 1350 WP_059179826.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11914.68 Da        Isoelectric Point: 9.5735

>T81515 WP_059179822.1 NZ_CP023529:c3761508-3761191 [Lelliottia amnigena]
MKEIVQTESFRCWEQNVNDPRAKTLIAARLFRLANGLPGDVKPVGEGISELRIHYGPGYRIYFKSQGNVLIILLSGGNKN
SQDKDIILAKTLARSLEHREFIHHD

Download         Length: 318 bp

>T81515 NZ_CP023529:c3761508-3761191 [Lelliottia amnigena]
ATGAAGGAGATTGTTCAAACAGAATCCTTCCGTTGCTGGGAGCAAAACGTAAACGATCCACGTGCAAAAACGCTTATTGC
AGCGCGTTTATTCCGCCTGGCTAATGGTCTGCCGGGGGATGTAAAACCTGTTGGAGAAGGTATCAGCGAGCTACGGATTC
ATTACGGCCCGGGTTACAGGATCTATTTTAAATCGCAGGGAAACGTACTGATCATTTTGCTCAGTGGCGGCAATAAAAAT
AGTCAGGATAAAGACATCATTCTGGCAAAGACACTCGCAAGATCACTCGAACATCGGGAGTTTATACACCATGACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10166.62 Da        Isoelectric Point: 5.0492

>AT81515 WP_059179821.1 NZ_CP023529:c3761198-3760911 [Lelliottia amnigena]
MTELTHYDPARALINDDEISVFMADALETGDSAYIAKALGIVARAKGMSTIATQTGLSREQLYRSFSEKGNPTLKTTLAV
MKALGLGLTIKSAED

Download         Length: 288 bp

>AT81515 NZ_CP023529:c3761198-3760911 [Lelliottia amnigena]
ATGACTGAACTCACTCATTACGATCCTGCCCGGGCGCTTATCAATGATGATGAAATTAGCGTATTCATGGCTGATGCGCT
AGAAACTGGCGATTCTGCCTACATTGCTAAAGCATTAGGGATCGTTGCCCGCGCAAAAGGAATGTCTACCATTGCGACAC
AAACGGGTTTGTCTCGCGAACAGCTGTATCGCTCTTTTAGTGAAAAAGGTAACCCAACGCTTAAAACCACGCTTGCCGTT
ATGAAAGCGCTGGGTCTTGGATTGACGATTAAAAGTGCTGAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5XVP2

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XWI6

References