Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2550460..2551120 Replicon chromosome
Accession NZ_CP023529
Organism Lelliottia amnigena strain FDAARGOS_395

Toxin (Protein)


Gene name cptA Uniprot ID A0A3S5XTW2
Locus tag CO697_RS12435 Protein ID WP_059177602.1
Coordinates 2550460..2550873 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3S5XU93
Locus tag CO697_RS12440 Protein ID WP_015960306.1
Coordinates 2550854..2551120 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO697_RS12415 2546456..2548189 - 1734 WP_059177606.1 single-stranded-DNA-specific exonuclease RecJ -
CO697_RS12420 2548195..2548908 - 714 WP_059177605.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CO697_RS12425 2548937..2549833 - 897 WP_059177604.1 site-specific tyrosine recombinase XerD -
CO697_RS12430 2549934..2550455 + 522 WP_059177603.1 flavodoxin FldB -
CO697_RS12435 2550460..2550873 - 414 WP_059177602.1 protein YgfX Toxin
CO697_RS12440 2550854..2551120 - 267 WP_015960306.1 FAD assembly factor SdhE Antitoxin
CO697_RS12445 2551388..2552368 + 981 WP_059177601.1 tRNA-modifying protein YgfZ -
CO697_RS12450 2552411..2553070 - 660 WP_059177600.1 hemolysin III family protein -
CO697_RS12455 2553234..2553545 - 312 WP_059178027.1 N(4)-acetylcytidine aminohydrolase -
CO697_RS12460 2553598..2554329 + 732 WP_059177599.1 MurR/RpiR family transcriptional regulator -
CO697_RS12465 2554445..2555878 + 1434 WP_059177598.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16260.13 Da        Isoelectric Point: 11.1910

>T81512 WP_059177602.1 NZ_CP023529:c2550873-2550460 [Lelliottia amnigena]
VVLWQSDLRVSWRSQWMSLLLHGMVAAFVLLMPWPLSYTPLWMLLLSLVVFDSVRSQRRINSCQGEIKLLMDSRLRWQGK
EWEIVGTPWMLSFGMMFRLRNVQGGRNQHLWLSADSMDADEWRDLRRMVLQQPTPGR

Download         Length: 414 bp

>T81512 NZ_CP023529:c2550873-2550460 [Lelliottia amnigena]
GTGGTCCTGTGGCAATCTGATCTGCGCGTATCCTGGCGCTCACAGTGGATGTCTTTGTTGCTCCACGGAATGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCACTCAGCTACACCCCGTTATGGATGCTGTTACTCTCGCTTGTGGTGTTCGACAGCG
TGCGCAGCCAGCGACGTATCAATTCCTGTCAGGGCGAAATCAAGCTGCTGATGGACTCTCGTCTGCGCTGGCAAGGTAAA
GAGTGGGAAATCGTCGGTACGCCCTGGATGCTGAGTTTTGGCATGATGTTTCGCTTGCGTAACGTGCAAGGCGGACGAAA
CCAGCATTTATGGCTTTCGGCGGACAGTATGGATGCTGACGAGTGGCGAGATTTGCGTCGGATGGTTTTGCAGCAACCGA
CGCCCGGTCGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10528.00 Da        Isoelectric Point: 5.1340

>AT81512 WP_015960306.1 NZ_CP023529:c2551120-2550854 [Lelliottia amnigena]
MDISNKARIHWACRRGMRELDISVMPFFEYEYDSLSDDDKRLFIRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT81512 NZ_CP023529:c2551120-2550854 [Lelliottia amnigena]
ATGGACATTAGCAATAAGGCTCGTATTCACTGGGCGTGCCGCCGCGGCATGCGCGAACTTGATATTTCCGTCATGCCATT
CTTCGAATATGAATACGACAGCTTAAGCGATGACGATAAGCGTCTGTTTATTCGCCTTCTTGAAAGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5XTW2

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XU93

References