Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1179248..1180807 Replicon chromosome
Accession NZ_CP023529
Organism Lelliottia amnigena strain FDAARGOS_395

Toxin (Protein)


Gene name hipA Uniprot ID A0A3S5XQH7
Locus tag CO697_RS05820 Protein ID WP_059178935.1
Coordinates 1179248..1180555 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A3S5XQW5
Locus tag CO697_RS05825 Protein ID WP_012017425.1
Coordinates 1180556..1180807 (-) Length 84 a.a.

Genomic Context


CO697_RS05795CO697_RS05800CO697_RS05805CO697_RS05835CO697_RS05845CO697_RS05810CO697_RS05815CO697_RS05820CO697_RS05825CO697_RS05830CO697_RS05840
Location: 1174757..1175104 (348 bp)
Type: Others
Protein ID: WP_096759582.1
Location: 1175468..1175755 (288 bp)
Type: Others
Protein ID: WP_059178932.1
Location: 1175763..1177070 (1308 bp)
Type: Others
Protein ID: WP_174521007.1
Location: 1181453..1182661 (1209 bp)
Type: Others
Protein ID: WP_059178937.1
Location: 1184263..1185225 (963 bp)
Type: Others
Protein ID: WP_059178939.1
Location: 1177083..1177844 (762 bp)
Type: Others
Protein ID: WP_059178933.1
Location: 1177887..1179107 (1221 bp)
Type: Others
Protein ID: WP_059178934.1
Location: 1179248..1180555 (1308 bp)
Type: Toxin
Protein ID: WP_059178935.1
Location: 1180556..1180807 (252 bp)
Type: Antitoxin
Protein ID: WP_012017425.1
Location: 1180895..1181359 (465 bp)
Type: Others
Protein ID: WP_059178936.1
Location: 1182594..1184111 (1518 bp)
Type: Others
Protein ID: WP_059178938.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CO697_RS057951174757..1175104+348WP_096759582.1hypothetical protein-
CO697_RS058001175468..1175755+288WP_059178932.1VF530 family protein-
CO697_RS058051175763..1177070+1308WP_174521007.1glycoside hydrolase family 10 protein-
CO697_RS058101177083..1177844-762WP_059178933.1thiol:disulfide interchange protein DsbG-
CO697_RS058151177887..1179107-1221WP_059178934.1diguanylate phosphodiesterase-
CO697_RS058201179248..1180555-1308WP_059178935.1type II toxin-antitoxin system HipA family toxinToxin
CO697_RS058251180556..1180807-252WP_012017425.1helix-turn-helix domain-containing proteinAntitoxin
CO697_RS058301180895..1181359-465WP_059178936.1helix-turn-helix transcriptional regulator-
CO697_RS058351181453..1182661+1209WP_059178937.1MFS transporter-
CO697_RS058401182594..1184111-1518WP_059178938.1alpha/beta hydrolase-
CO697_RS058451184263..1185225+963WP_059178939.1mannuronate-specific alginate lyase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-105)

Antitoxin

(10-64)


Sequences


Toxin        


Download         Length: 436 a.a.        Molecular weight: 49182.29 Da        Isoelectric Point: 8.6915

>T81502 WP_059178935.1 NZ_CP023529:c1180555-1179248 [Lelliottia amnigena]
MKTSKLTVAMNGTVVGTLYRNGKGAMSWQYAQTWLDTPGARVISQSLPLTPRRQEGEVVYNFFSNLLPDSQAIISRMQTR
FKIPTDHPFDLLASVGRDCVGAIQLYPENSEIPPVTHMQATPLSDNEIAALLEGYRNAPLGMNDDQDFRISIAGAQEKTA
LLWHQNRWQRPNGSTPTSHIFKLPIGKIEQNNIDLSESCENEWLCLRLAREFGFSVAEATLATYADKKVLIVERFDRKWS
RDGKWLMRLPQEDMCQALGYSPALKYESHGGPGIAEIMTLLLGSRRSNQDRETFFRTQIFYWLTGAIDGHAKNYSVFIEP
DSAYVMTPLYDILSAYPVFGPKGISAQKAKMAMALQGKNRQYHWAQIQPRHFPATAERVGFSAIRAKKMMIEMGNATNEI
IERVRQSLPIDFPTHISEAIFNGMAKQAERLIRLE

Download         Length: 1308 bp

>T81502 NZ_CP023529:c1180555-1179248 [Lelliottia amnigena]
ATGAAAACCAGTAAGCTGACCGTTGCGATGAACGGTACGGTTGTCGGCACGCTGTATCGTAATGGAAAAGGGGCAATGTC
CTGGCAATATGCGCAGACATGGCTCGACACGCCGGGCGCGCGCGTGATTTCACAGTCGCTACCGTTAACGCCGCGTCGTC
AGGAAGGCGAGGTGGTGTATAACTTCTTTAGTAATTTGCTGCCTGACTCGCAGGCGATTATCTCGCGTATGCAAACGCGC
TTTAAAATCCCCACGGATCATCCCTTCGATTTGCTGGCAAGCGTTGGCCGCGACTGTGTTGGGGCAATCCAGCTCTACCC
GGAAAACAGTGAAATACCCCCTGTGACGCACATGCAGGCCACGCCGCTTTCCGATAACGAGATTGCGGCACTGCTGGAAG
GGTATCGTAATGCGCCATTGGGGATGAATGACGACCAGGATTTCAGGATTTCCATTGCAGGTGCGCAGGAAAAAACGGCA
CTGCTCTGGCATCAGAACCGCTGGCAACGCCCCAACGGCAGCACGCCCACCAGCCATATTTTCAAACTGCCCATCGGTAA
AATTGAGCAGAACAATATCGATCTGAGTGAAAGCTGCGAGAACGAATGGCTGTGTCTGCGCCTTGCCCGTGAATTCGGTT
TTTCGGTCGCCGAGGCAACGTTAGCAACCTATGCCGACAAAAAAGTGCTGATTGTTGAGCGTTTTGATCGTAAATGGTCA
CGAGACGGAAAGTGGCTGATGCGACTCCCGCAAGAAGATATGTGTCAGGCTCTCGGGTATTCACCGGCGCTGAAATATGA
ATCTCACGGCGGCCCCGGCATCGCCGAAATCATGACCTTGCTGTTGGGATCGCGCCGCTCAAACCAGGATCGCGAAACGT
TTTTCCGCACTCAGATATTTTACTGGCTGACAGGCGCGATCGATGGCCACGCAAAAAATTACAGTGTGTTTATCGAACCC
GATTCGGCGTACGTTATGACGCCGCTATACGATATTTTGTCAGCCTATCCGGTCTTCGGGCCAAAAGGAATTTCCGCACA
AAAAGCGAAAATGGCCATGGCGTTGCAGGGCAAAAACCGGCAATACCACTGGGCTCAGATTCAACCACGCCATTTCCCGG
CTACGGCTGAACGCGTTGGTTTTTCAGCTATACGCGCAAAAAAGATGATGATCGAAATGGGAAATGCGACAAATGAGATT
ATCGAGCGGGTACGTCAGTCGTTACCGATTGATTTCCCGACACATATCAGCGAAGCGATTTTTAACGGGATGGCGAAGCA
AGCTGAAAGGCTAATACGTTTAGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9323.55 Da        Isoelectric Point: 5.0790

>AT81502 WP_012017425.1 NZ_CP023529:c1180807-1180556 [Lelliottia amnigena]
MKITTSTMLANAMRDQRKALELTQAEAAERVGMKQTTVSGFEQNPDTSKLETLFRLLSALDLELHVVPRGQASEKDSGWT
QEW

Download         Length: 252 bp

>AT81502 NZ_CP023529:c1180807-1180556 [Lelliottia amnigena]
ATGAAAATTACCACATCAACCATGCTGGCCAATGCCATGCGAGATCAGCGCAAAGCGCTGGAACTGACTCAAGCAGAAGC
CGCCGAACGCGTGGGGATGAAGCAAACCACGGTATCAGGCTTTGAACAAAATCCGGATACCAGCAAGCTGGAAACGCTAT
TTCGTCTGCTTTCAGCACTGGATTTAGAACTGCACGTTGTGCCCCGGGGCCAGGCGTCAGAAAAGGACAGCGGCTGGACG
CAGGAGTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A3S5XQH7


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3S5XQW5

References