Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1179248..1180807 Replicon chromosome
Accession NZ_CP023529
Organism Lelliottia amnigena strain FDAARGOS_395

Toxin (Protein)


Gene name hipA Uniprot ID A0A3S5XQH7
Locus tag CO697_RS05820 Protein ID WP_059178935.1
Coordinates 1179248..1180555 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A3S5XQW5
Locus tag CO697_RS05825 Protein ID WP_012017425.1
Coordinates 1180556..1180807 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO697_RS05795 1174757..1175104 + 348 WP_096759582.1 hypothetical protein -
CO697_RS05800 1175468..1175755 + 288 WP_059178932.1 VF530 family protein -
CO697_RS05805 1175763..1177070 + 1308 WP_174521007.1 glycoside hydrolase family 10 protein -
CO697_RS05810 1177083..1177844 - 762 WP_059178933.1 thiol:disulfide interchange protein DsbG -
CO697_RS05815 1177887..1179107 - 1221 WP_059178934.1 diguanylate phosphodiesterase -
CO697_RS05820 1179248..1180555 - 1308 WP_059178935.1 type II toxin-antitoxin system HipA family toxin Toxin
CO697_RS05825 1180556..1180807 - 252 WP_012017425.1 helix-turn-helix domain-containing protein Antitoxin
CO697_RS05830 1180895..1181359 - 465 WP_059178936.1 helix-turn-helix transcriptional regulator -
CO697_RS05835 1181453..1182661 + 1209 WP_059178937.1 MFS transporter -
CO697_RS05840 1182594..1184111 - 1518 WP_059178938.1 alpha/beta hydrolase -
CO697_RS05845 1184263..1185225 + 963 WP_059178939.1 mannuronate-specific alginate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 49182.29 Da        Isoelectric Point: 8.6915

>T81502 WP_059178935.1 NZ_CP023529:c1180555-1179248 [Lelliottia amnigena]
MKTSKLTVAMNGTVVGTLYRNGKGAMSWQYAQTWLDTPGARVISQSLPLTPRRQEGEVVYNFFSNLLPDSQAIISRMQTR
FKIPTDHPFDLLASVGRDCVGAIQLYPENSEIPPVTHMQATPLSDNEIAALLEGYRNAPLGMNDDQDFRISIAGAQEKTA
LLWHQNRWQRPNGSTPTSHIFKLPIGKIEQNNIDLSESCENEWLCLRLAREFGFSVAEATLATYADKKVLIVERFDRKWS
RDGKWLMRLPQEDMCQALGYSPALKYESHGGPGIAEIMTLLLGSRRSNQDRETFFRTQIFYWLTGAIDGHAKNYSVFIEP
DSAYVMTPLYDILSAYPVFGPKGISAQKAKMAMALQGKNRQYHWAQIQPRHFPATAERVGFSAIRAKKMMIEMGNATNEI
IERVRQSLPIDFPTHISEAIFNGMAKQAERLIRLE

Download         Length: 1308 bp

>T81502 NZ_CP023529:c1180555-1179248 [Lelliottia amnigena]
ATGAAAACCAGTAAGCTGACCGTTGCGATGAACGGTACGGTTGTCGGCACGCTGTATCGTAATGGAAAAGGGGCAATGTC
CTGGCAATATGCGCAGACATGGCTCGACACGCCGGGCGCGCGCGTGATTTCACAGTCGCTACCGTTAACGCCGCGTCGTC
AGGAAGGCGAGGTGGTGTATAACTTCTTTAGTAATTTGCTGCCTGACTCGCAGGCGATTATCTCGCGTATGCAAACGCGC
TTTAAAATCCCCACGGATCATCCCTTCGATTTGCTGGCAAGCGTTGGCCGCGACTGTGTTGGGGCAATCCAGCTCTACCC
GGAAAACAGTGAAATACCCCCTGTGACGCACATGCAGGCCACGCCGCTTTCCGATAACGAGATTGCGGCACTGCTGGAAG
GGTATCGTAATGCGCCATTGGGGATGAATGACGACCAGGATTTCAGGATTTCCATTGCAGGTGCGCAGGAAAAAACGGCA
CTGCTCTGGCATCAGAACCGCTGGCAACGCCCCAACGGCAGCACGCCCACCAGCCATATTTTCAAACTGCCCATCGGTAA
AATTGAGCAGAACAATATCGATCTGAGTGAAAGCTGCGAGAACGAATGGCTGTGTCTGCGCCTTGCCCGTGAATTCGGTT
TTTCGGTCGCCGAGGCAACGTTAGCAACCTATGCCGACAAAAAAGTGCTGATTGTTGAGCGTTTTGATCGTAAATGGTCA
CGAGACGGAAAGTGGCTGATGCGACTCCCGCAAGAAGATATGTGTCAGGCTCTCGGGTATTCACCGGCGCTGAAATATGA
ATCTCACGGCGGCCCCGGCATCGCCGAAATCATGACCTTGCTGTTGGGATCGCGCCGCTCAAACCAGGATCGCGAAACGT
TTTTCCGCACTCAGATATTTTACTGGCTGACAGGCGCGATCGATGGCCACGCAAAAAATTACAGTGTGTTTATCGAACCC
GATTCGGCGTACGTTATGACGCCGCTATACGATATTTTGTCAGCCTATCCGGTCTTCGGGCCAAAAGGAATTTCCGCACA
AAAAGCGAAAATGGCCATGGCGTTGCAGGGCAAAAACCGGCAATACCACTGGGCTCAGATTCAACCACGCCATTTCCCGG
CTACGGCTGAACGCGTTGGTTTTTCAGCTATACGCGCAAAAAAGATGATGATCGAAATGGGAAATGCGACAAATGAGATT
ATCGAGCGGGTACGTCAGTCGTTACCGATTGATTTCCCGACACATATCAGCGAAGCGATTTTTAACGGGATGGCGAAGCA
AGCTGAAAGGCTAATACGTTTAGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9323.55 Da        Isoelectric Point: 5.0790

>AT81502 WP_012017425.1 NZ_CP023529:c1180807-1180556 [Lelliottia amnigena]
MKITTSTMLANAMRDQRKALELTQAEAAERVGMKQTTVSGFEQNPDTSKLETLFRLLSALDLELHVVPRGQASEKDSGWT
QEW

Download         Length: 252 bp

>AT81502 NZ_CP023529:c1180807-1180556 [Lelliottia amnigena]
ATGAAAATTACCACATCAACCATGCTGGCCAATGCCATGCGAGATCAGCGCAAAGCGCTGGAACTGACTCAAGCAGAAGC
CGCCGAACGCGTGGGGATGAAGCAAACCACGGTATCAGGCTTTGAACAAAATCCGGATACCAGCAAGCTGGAAACGCTAT
TTCGTCTGCTTTCAGCACTGGATTTAGAACTGCACGTTGTGCCCCGGGGCCAGGCGTCAGAAAAGGACAGCGGCTGGACG
CAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5XQH7

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XQW5

References