Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3765481..3766135 Replicon chromosome
Accession NZ_CP023527
Organism Citrobacter koseri strain FDAARGOS_393

Toxin (Protein)


Gene name cptA Uniprot ID A0A078LNB4
Locus tag CO700_RS18370 Protein ID WP_024130921.1
Coordinates 3765481..3765888 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A078LG12
Locus tag CO700_RS18375 Protein ID WP_024130922.1
Coordinates 3765869..3766135 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO700_RS18350 3761383..3763116 - 1734 WP_049008966.1 single-stranded-DNA-specific exonuclease RecJ -
CO700_RS18355 3763122..3763835 - 714 WP_012134997.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CO700_RS18360 3763859..3764755 - 897 WP_012134998.1 site-specific tyrosine recombinase XerD -
CO700_RS18365 3764859..3765383 + 525 WP_012134999.1 flavodoxin FldB -
CO700_RS18370 3765481..3765888 - 408 WP_024130921.1 protein YgfX Toxin
CO700_RS18375 3765869..3766135 - 267 WP_024130922.1 FAD assembly factor SdhE Antitoxin
CO700_RS18385 3766392..3767372 + 981 WP_058668058.1 tRNA-modifying protein YgfZ -
CO700_RS18390 3767526..3768185 - 660 WP_058668059.1 hemolysin III family protein -
CO700_RS18395 3768347..3768658 - 312 WP_012135005.1 N(4)-acetylcytidine aminohydrolase -
CO700_RS18400 3768711..3769439 + 729 WP_012135006.1 MurR/RpiR family transcriptional regulator -
CO700_RS18405 3769560..3770993 + 1434 WP_058668060.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15888.77 Da        Isoelectric Point: 11.2845

>T81499 WP_024130921.1 NZ_CP023527:c3765888-3765481 [Citrobacter koseri]
VVLWQSDLRVSWRAQWLSLLIHGLVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRINTRQGEIKLLMDGRLRWQGQ
DWTIQGPPWMLKTGMMLRLRADSGKRQHLWLAADSMDDAEWRDLRRLMLQQATQG

Download         Length: 408 bp

>T81499 NZ_CP023527:c3765888-3765481 [Citrobacter koseri]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAATGGCTCTCTTTGCTCATTCATGGGCTTGTCGCCGC
ATTGGTTTTATTGATGCCCTGGCCATTGAGCTACACGCCGCTCTGGCTGATATTGCTTTCGCTGGTGGTGTTCGACTGTG
TGCGCAGTCAGCGGCGGATTAATACCCGGCAGGGCGAAATTAAACTGCTGATGGATGGGCGTTTACGTTGGCAAGGGCAA
GACTGGACGATTCAGGGTCCGCCCTGGATGCTTAAAACCGGCATGATGCTGCGTTTGCGCGCCGACAGCGGGAAGCGCCA
GCACTTGTGGCTGGCGGCGGACAGCATGGATGACGCCGAGTGGCGGGATTTACGGCGGTTAATGTTGCAACAGGCGACGC
AGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10476.00 Da        Isoelectric Point: 4.8836

>AT81499 WP_024130922.1 NZ_CP023527:c3766135-3765869 [Citrobacter koseri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKCIFVRLLECDDPDLFNWLMNHGKPGDAELEQMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT81499 NZ_CP023527:c3766135-3765869 [Citrobacter koseri]
ATGGATATTAATAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTCGACATTTCTATCATGCCGTT
TTTCGAACATGAGTACGATAACTTAAGCGATGAAGAAAAATGCATCTTTGTTCGTTTGCTGGAATGCGACGATCCTGATT
TATTTAACTGGTTGATGAACCACGGTAAACCGGGTGATGCAGAGCTGGAACAAATGGTGAAACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A078LNB4

Antitoxin

Source ID Structure
AlphaFold DB A0A078LG12

References