Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 833096..833799 Replicon chromosome
Accession NZ_CP023527
Organism Citrobacter koseri strain FDAARGOS_393

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag CO700_RS03970 Protein ID WP_058668643.1
Coordinates 833434..833799 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag CO700_RS03965 Protein ID WP_058668642.1
Coordinates 833096..833413 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO700_RS03925 828718..828954 + 237 WP_001144029.1 hypothetical protein -
CO700_RS03930 828954..829394 + 441 WP_058668635.1 hypothetical protein -
CO700_RS03935 829418..829882 + 465 WP_058668636.1 hypothetical protein -
CO700_RS03940 830461..831258 - 798 WP_125337065.1 hypothetical protein -
CO700_RS23960 831525..831796 + 272 Protein_739 DUF905 family protein -
CO700_RS03950 831899..832357 + 459 WP_058668639.1 antirestriction protein -
CO700_RS03955 832366..832848 + 483 WP_058668640.1 DNA repair protein RadC -
CO700_RS03960 832857..833078 + 222 WP_058668641.1 DUF987 domain-containing protein -
CO700_RS03965 833096..833413 + 318 WP_058668642.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CO700_RS03970 833434..833799 + 366 WP_058668643.1 TA system toxin CbtA family protein Toxin
CO700_RS03975 834059..835090 - 1032 WP_058668644.1 methionine synthase -
CO700_RS03980 835118..836101 - 984 WP_058668645.1 DUF1852 domain-containing protein -
CO700_RS03985 836371..837594 - 1224 WP_058668646.1 Zn-dependent hydrolase -
CO700_RS03990 837591..838073 - 483 WP_012133757.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13610.76 Da        Isoelectric Point: 8.2762

>T81485 WP_058668643.1 NZ_CP023527:833434-833799 [Citrobacter koseri]
MKTLPATISRAAKPCLSPVAVWQMLLARLLEKHYGLTLNDTPFFDESVIQEHIDAGITLANAVNFLVEKYELVRINRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSR

Download         Length: 366 bp

>T81485 NZ_CP023527:833434-833799 [Citrobacter koseri]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCTCCAGTGGCTGTCTGGCAAATGTTACTGGC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTTTGATGAATCCGTTATACAGGAACATATCG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAAAAGTATGAGTTAGTACGTATCAATCGCACAGGATTT
ACCTCACAGGAACAAGCGCCATATTTGACCGTGACAGATATCCTTCATGCCAGGAGAGCATGCGGATTAATGAACAGTTG
TTCGTATCGTGAAGTAAGTAATATTGTTCTTAGCCGATCGCGGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11949.62 Da        Isoelectric Point: 7.3230

>AT81485 WP_058668642.1 NZ_CP023527:833096-833413 [Citrobacter koseri]
MKNTTWGLQRDITPRLGARLMQEGNRLHYLADRASITGKFSDTECLKLDFAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT81485 NZ_CP023527:833096-833413 [Citrobacter koseri]
ATGAAAAACACCACATGGGGCCTACAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGATGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGGGCAAGTATCACCGGTAAGTTTAGTGATACCGAATGCCTGAAGTTGGATTTCGCATTCCCGC
ATTTTATCAGTCAGATGGAATCAATGCTGACTACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATATATCGCTGTTTATCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References