Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 68786..69525 Replicon plasmid unnamed
Accession NZ_CP023526
Organism Cedecea neteri strain FDAARGOS_392

Toxin (Protein)


Gene name tacT Uniprot ID A0A291E673
Locus tag CO704_RS25170 Protein ID WP_061278097.1
Coordinates 69040..69525 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A291E5R7
Locus tag CO704_RS25165 Protein ID WP_061278095.1
Coordinates 68786..69052 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO704_RS25150 63891..66896 - 3006 WP_061279134.1 Tn3 family transposase -
CO704_RS25155 67060..67605 + 546 WP_061279136.1 recombinase family protein -
CO704_RS25160 67651..68133 + 483 WP_061279138.1 lipopolysaccharide transport periplasmic protein LptA -
CO704_RS25165 68786..69052 + 267 WP_061278095.1 DUF1778 domain-containing protein Antitoxin
CO704_RS25170 69040..69525 + 486 WP_061278097.1 GNAT family N-acetyltransferase Toxin
CO704_RS25175 69722..71068 + 1347 WP_082763257.1 ISNCY family transposase -
CO704_RS25185 72126..72419 - 294 WP_061278100.1 hypothetical protein -
CO704_RS25190 72851..73177 - 327 WP_061278102.1 type II toxin-antitoxin system RelE/ParE family toxin -
CO704_RS25195 73177..73404 - 228 WP_061278104.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CO704_RS25205 73648..74027 - 380 Protein_58 IS3 family transposase -
CO704_RS25210 74283..74483 - 201 WP_138089311.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..254496 254496
- inside IScluster/Tn - - 63891..71068 7177


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17652.41 Da        Isoelectric Point: 9.6281

>T81484 WP_061278097.1 NZ_CP023526:69040-69525 [Cedecea neteri]
VGRVTAPAPLSSDHQVAEFISGEVVLDDWLRQKSLKNQALGAARTFVVCKAETKRVVGFYSLATGSVNHVEATGNLRRNM
PDPIPVIILARLAVDITFHGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTDEAKAFYIHHGFKVSQTQARTLFLRLP
Q

Download         Length: 486 bp

>T81484 NZ_CP023526:69040-69525 [Cedecea neteri]
GTGGGACGTGTAACCGCGCCAGCCCCGTTATCCAGCGATCATCAGGTGGCGGAGTTCATCAGTGGAGAAGTTGTGCTCGA
TGACTGGCTCAGACAGAAAAGCTTAAAAAATCAGGCCCTCGGGGCGGCCCGCACGTTCGTTGTCTGTAAAGCAGAGACGA
AGCGCGTTGTTGGTTTTTACTCCCTGGCCACCGGCAGTGTTAACCATGTGGAAGCCACGGGGAATCTCCGACGCAATATG
CCTGATCCGATCCCCGTCATCATACTTGCGCGTCTGGCTGTTGACATCACATTCCACGGACAAGGACTTGGCGCTGATTT
ATTGCATGATGCCGTGCTGCGCTGCTATCGGGTTGCAGAGAATATTGGCGTACGGGCAATCATGGTTCACGCGCTGACAG
ATGAAGCGAAAGCTTTTTATATTCATCATGGCTTTAAGGTATCTCAGACACAGGCGCGGACCCTGTTCCTCAGGCTACCT
CAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10177.62 Da        Isoelectric Point: 4.4857

>AT81484 WP_061278095.1 NZ_CP023526:68786-69052 [Cedecea neteri]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYVEFIDMLDAPVTDEPAINKLL
TRKPQWDV

Download         Length: 267 bp

>AT81484 NZ_CP023526:68786-69052 [Cedecea neteri]
ATGAAATCAGATGTTCAGCTCAACCTCAGAGCGAAGGAATCTCAAAGAGCGCTTATTGATGCTGCGGCAGAGATCCTCCA
TAAATCACGTACAGACTTCATTCTGGAAATGGCCTGTCAGGCTGCAGAGAACGTGATCCTCGACCGTCGTGTATTCAATT
TCAACGATGAACAGTATGTCGAGTTTATCGATATGCTTGATGCCCCTGTCACGGATGAGCCCGCGATTAACAAACTGCTG
ACAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E673

Antitoxin

Source ID Structure
AlphaFold DB A0A291E5R7

References