Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5123726..5124360 Replicon chromosome
Accession NZ_CP023525
Organism Cedecea neteri strain FDAARGOS_392

Toxin (Protein)


Gene name vapC Uniprot ID A0A291E577
Locus tag CO704_RS24475 Protein ID WP_061273301.1
Coordinates 5123956..5124360 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A291E4N4
Locus tag CO704_RS24470 Protein ID WP_061273299.1
Coordinates 5123726..5123956 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO704_RS24455 5119866..5121986 - 2121 WP_061273293.1 UDP-forming cellulose synthase catalytic subunit -
CO704_RS24460 5122003..5122806 - 804 WP_061273295.1 cellulose synthase operon protein YhjQ -
CO704_RS24465 5122797..5123375 - 579 WP_061273297.1 cellulose biosynthesis protein BcsO -
CO704_RS24470 5123726..5123956 + 231 WP_061273299.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CO704_RS24475 5123956..5124360 + 405 WP_061273301.1 tRNA(fMet)-specific endonuclease VapC Toxin
CO704_RS24480 5124443..5124973 - 531 WP_061273303.1 hypothetical protein -
CO704_RS24485 5125112..5125303 + 192 WP_061273305.1 toxin-antitoxin system HicB family antitoxin -
CO704_RS24490 5125388..5126395 - 1008 WP_061273307.1 ABC transporter ATP-binding protein -
CO704_RS24495 5126392..5127375 - 984 WP_039298855.1 dipeptide ABC transporter ATP-binding protein -
CO704_RS24500 5127386..5128288 - 903 WP_061273309.1 dipeptide ABC transporter permease DppC -
CO704_RS24505 5128298..5129317 - 1020 WP_061273312.1 dipeptide ABC transporter permease DppB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15001.41 Da        Isoelectric Point: 7.8388

>T81483 WP_061273301.1 NZ_CP023525:5123956-5124360 [Cedecea neteri]
MLKYMLDTNICIFTIKNKPQVVREAFNRYYGQMCISSVTLMELIYGAEKSLYPEKNLAVIEGFAARLEVLPYGTDAAIHT
GQARAELAKKGTSIGPYDSMIAGHARSLGLVVVTNNLREFERVPGLRLEDWTVQ

Download         Length: 405 bp

>T81483 NZ_CP023525:5123956-5124360 [Cedecea neteri]
ATGCTTAAATATATGCTGGATACCAATATTTGCATCTTTACCATAAAGAATAAGCCGCAGGTCGTCCGCGAAGCCTTTAA
TCGATATTACGGACAAATGTGCATCAGCTCGGTCACGTTGATGGAGCTGATTTATGGTGCTGAAAAGTCACTTTATCCAG
AAAAGAATCTGGCCGTTATTGAAGGATTTGCGGCCCGCCTGGAAGTTCTTCCGTACGGTACTGATGCGGCAATACACACC
GGGCAGGCTCGGGCTGAACTGGCAAAAAAAGGGACGTCGATTGGGCCTTATGACAGCATGATAGCCGGGCATGCACGCTC
TCTTGGCTTAGTTGTCGTGACCAATAATCTTCGGGAATTTGAGCGTGTACCGGGGCTAAGGCTGGAAGACTGGACGGTGC
AGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8532.57 Da        Isoelectric Point: 4.7672

>AT81483 WP_061273299.1 NZ_CP023525:5123726-5123956 [Cedecea neteri]
MEKTTVFKSNRSQAVRLPKAVALPEDVKHVDIVAIGRTRVITPAGEGWDSWFNGDSVTADFMADREQPGEQLREEF

Download         Length: 231 bp

>AT81483 NZ_CP023525:5123726-5123956 [Cedecea neteri]
ATGGAAAAAACTACCGTATTTAAAAGTAACCGTAGCCAGGCCGTTCGCCTGCCTAAAGCGGTTGCGTTACCGGAAGATGT
GAAACATGTCGATATTGTCGCTATCGGCAGAACACGGGTGATCACACCGGCGGGTGAAGGCTGGGATAGCTGGTTCAATG
GCGACAGCGTGACGGCTGATTTTATGGCAGATAGAGAGCAACCGGGCGAACAACTCAGGGAAGAATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E577

Antitoxin

Source ID Structure
AlphaFold DB A0A291E4N4

References