Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3208038..3208621 Replicon chromosome
Accession NZ_CP023525
Organism Cedecea neteri strain FDAARGOS_392

Toxin (Protein)


Gene name mazF Uniprot ID A0A291E0B1
Locus tag CO704_RS15280 Protein ID WP_061274092.1
Coordinates 3208289..3208621 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A291DZZ4
Locus tag CO704_RS15275 Protein ID WP_061274090.1
Coordinates 3208038..3208289 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO704_RS15240 3203559..3204013 + 455 Protein_2970 DUF4756 family protein -
CO704_RS15245 3204317..3205081 + 765 WP_082763188.1 DUF4145 domain-containing protein -
CO704_RS15250 3205269..3206093 - 825 WP_061274080.1 hypothetical protein -
CO704_RS15255 3206351..3206716 - 366 WP_061274082.1 hypothetical protein -
CO704_RS15260 3206756..3207103 - 348 WP_061274084.1 hypothetical protein -
CO704_RS15265 3207215..3207514 - 300 WP_061274086.1 hypothetical protein -
CO704_RS15270 3207511..3207783 - 273 WP_061274088.1 AlpA family transcriptional regulator -
CO704_RS15275 3208038..3208289 + 252 WP_061274090.1 hypothetical protein Antitoxin
CO704_RS15280 3208289..3208621 + 333 WP_061274092.1 endoribonuclease MazF Toxin
CO704_RS15285 3208885..3210582 - 1698 WP_061274094.1 hypothetical protein -
CO704_RS15290 3210579..3212489 - 1911 WP_061274096.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-106)

Antitoxin

Antitoxin PemI-like

(3-82)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12131.94 Da        Isoelectric Point: 7.0819

>T81480 WP_061274092.1 NZ_CP023525:3208289-3208621 [Cedecea neteri]
MVSRFVPDSGDLIWLDFDPVVGHEQGGHRPAVVLSPFPYNNLTGLCLCVPCTTQSKGYKFEVELSGDRESVALADQVTCV
DWRNRKATKKGKVTADELEIIRAKARVLIG

Download         Length: 333 bp

>T81480 NZ_CP023525:3208289-3208621 [Cedecea neteri]
ATGGTTTCTCGTTTTGTTCCTGATTCTGGCGACTTAATCTGGCTGGATTTTGATCCTGTAGTGGGGCATGAACAGGGAGG
ACACCGCCCCGCTGTTGTTCTTAGCCCCTTCCCCTACAATAACCTTACCGGACTTTGCTTATGTGTTCCCTGCACGACCC
AGAGCAAAGGATATAAATTTGAAGTCGAATTATCTGGAGACCGTGAAAGTGTGGCTCTCGCCGATCAGGTTACTTGTGTT
GACTGGCGCAACCGTAAGGCAACAAAGAAAGGCAAAGTAACAGCCGATGAGTTAGAAATCATCAGAGCAAAAGCTAGGGT
TCTGATTGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9419.87 Da        Isoelectric Point: 4.5859

>AT81480 WP_061274090.1 NZ_CP023525:3208038-3208289 [Cedecea neteri]
MIDVPVKKWGNSPAIRLSSSVMQAFDMTYNDSFDMEIRETEIALIPKKKPKYQFTLDELLEGMTADNVHEKVDFGAPVGK
ELL

Download         Length: 252 bp

>AT81480 NZ_CP023525:3208038-3208289 [Cedecea neteri]
ATGATTGATGTCCCGGTTAAAAAATGGGGGAACTCGCCTGCAATACGCCTTTCCTCATCTGTTATGCAAGCGTTTGATAT
GACCTATAACGATAGCTTTGACATGGAAATCAGGGAAACGGAAATAGCGCTGATCCCCAAGAAAAAGCCAAAGTATCAGT
TCACGCTGGATGAGTTGCTGGAAGGGATGACCGCCGATAACGTTCATGAGAAAGTCGATTTTGGCGCTCCAGTCGGTAAG
GAGCTGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E0B1

Antitoxin

Source ID Structure
AlphaFold DB A0A291DZZ4

References