Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1109993..1110611 Replicon chromosome
Accession NZ_CP023525
Organism Cedecea neteri strain FDAARGOS_392

Toxin (Protein)


Gene name Hha Uniprot ID S3J5Z6
Locus tag CO704_RS05345 Protein ID WP_008460299.1
Coordinates 1109993..1110208 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1X7LVC3
Locus tag CO704_RS05350 Protein ID WP_008460297.1
Coordinates 1110237..1110611 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO704_RS05320 1106151..1108055 + 1905 WP_061275310.1 methyl-accepting chemotaxis protein -
CO704_RS05325 1108180..1108440 + 261 WP_008460319.1 type B 50S ribosomal protein L31 -
CO704_RS05330 1108444..1108584 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
CO704_RS05335 1108588..1109064 - 477 WP_061275308.1 YlaC family protein -
CO704_RS05340 1109190..1109741 - 552 WP_061275306.1 maltose O-acetyltransferase -
CO704_RS05345 1109993..1110208 - 216 WP_008460299.1 hemolysin expression modulator Hha Toxin
CO704_RS05350 1110237..1110611 - 375 WP_008460297.1 Hha toxicity modulator TomB Antitoxin
CO704_RS05355 1111175..1114324 - 3150 WP_061275304.1 multidrug efflux RND transporter permease subunit AcrB -
CO704_RS05360 1114347..1115546 - 1200 WP_061275302.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8526.94 Da        Isoelectric Point: 9.4828

>T81469 WP_008460299.1 NZ_CP023525:c1110208-1109993 [Cedecea neteri]
MTTKLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 216 bp

>T81469 NZ_CP023525:c1110208-1109993 [Cedecea neteri]
ATGACTACCAAGCTCACCAAAACCGATTATTTGATGCGTCTCCGGCGTTGTCAGACAATTGATACGCTGGAACGCGTAAT
AGAAAAAAATAAATATGAATTATCAGATAATGAACTGGCGGTATTTTATTCAGCAGCCGATCACCGTCTTGCAGAACTGA
CGATGAATAAACTGTATGACAAAATCCCACCTTCAGTGTGGAAATTTATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14459.17 Da        Isoelectric Point: 5.1574

>AT81469 WP_008460297.1 NZ_CP023525:c1110611-1110237 [Cedecea neteri]
MDEYSPKRHDIAQLKFLCESLYHDCLTNLGESNHGWVNDPTSAINLQLNELIEHIAASALNYKIKYPDESKLIEQIDEYL
DDTFMLFSNYGINAQDLQRWRKSGNRLFRCFISESRANPVSHSF

Download         Length: 375 bp

>AT81469 NZ_CP023525:c1110611-1110237 [Cedecea neteri]
ATGGACGAATACTCACCAAAGCGGCATGATATCGCGCAGCTTAAGTTTCTCTGTGAGAGTCTGTATCACGATTGTCTGAC
CAATCTTGGTGAGAGCAATCATGGGTGGGTTAATGATCCTACATCGGCCATTAATCTACAGTTGAATGAATTGATTGAGC
ACATTGCCGCATCGGCGCTTAATTATAAGATTAAGTACCCTGATGAGAGCAAATTGATTGAACAGATTGATGAATACCTG
GACGATACTTTCATGTTATTTAGCAATTACGGCATTAATGCGCAAGATTTGCAGCGGTGGCGTAAATCAGGGAATCGCTT
GTTCAGATGTTTCATCAGCGAGAGCCGCGCTAACCCAGTAAGCCACTCGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X7LUT2

Antitoxin

Source ID Structure
AlphaFold DB A0A1X7LVC3

References