Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 861092..861830 Replicon chromosome
Accession NZ_CP023525
Organism Cedecea neteri strain FDAARGOS_392

Toxin (Protein)


Gene name yeeV Uniprot ID A0A291DUG1
Locus tag CO704_RS04190 Protein ID WP_061278633.1
Coordinates 861092..861472 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A291DUD4
Locus tag CO704_RS04195 Protein ID WP_061278631.1
Coordinates 861504..861830 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO704_RS04170 856508..857628 + 1121 WP_096753955.1 IS3 family transposase -
CO704_RS04175 858118..859359 - 1242 WP_061278639.1 integrase -
CO704_RS04180 859676..860512 - 837 WP_061278637.1 DUF4942 domain-containing protein -
CO704_RS04185 860604..861095 - 492 WP_061278635.1 hypothetical protein -
CO704_RS04190 861092..861472 - 381 WP_061278633.1 TA system toxin CbtA family protein Toxin
CO704_RS04195 861504..861830 - 327 WP_061278631.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CO704_RS04200 861841..862308 - 468 WP_096754170.1 DNA repair protein RadC -
CO704_RS04205 862323..862742 - 420 WP_061278627.1 antirestriction protein -
CO704_RS04210 862839..863297 - 459 WP_096753956.1 hypothetical protein -
CO704_RS04215 863322..863795 - 474 WP_061278625.1 hypothetical protein -
CO704_RS04220 863815..864510 - 696 WP_061278623.1 hypothetical protein -
CO704_RS04225 864771..865640 - 870 WP_061278621.1 GTPase family protein -
CO704_RS04230 865819..866364 - 546 WP_072279207.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 848674..866364 17690


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14110.06 Da        Isoelectric Point: 6.7093

>T81468 WP_061278633.1 NZ_CP023525:c861472-861092 [Cedecea neteri]
MQNLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLIDTPFGDDSVIQAHINAGISLCDAVNFIVERYELVRTDNSRF
NLSERSSLVSAIDILRARRATGLIVSSGYSTITRITTGRYREDKTQ

Download         Length: 381 bp

>T81468 NZ_CP023525:c861472-861092 [Cedecea neteri]
ATGCAAAATTTACCTTTACCCGAGCCACGGGCGGCTGAGCCATGCCCGTCGCCCGTGCAGGTCTGGCAACTGCTGCTCAC
ACATCTGCTGGATAAACACTATGGCCTCACGCTCATCGACACGCCGTTTGGCGACGACAGCGTAATTCAGGCGCACATCA
ACGCCGGTATCTCCCTGTGCGACGCCGTCAATTTCATTGTGGAAAGGTATGAGCTGGTACGTACCGACAACAGCCGTTTC
AACCTCAGCGAGCGCTCATCGCTAGTTAGTGCCATCGACATTCTGCGTGCCCGTCGTGCAACCGGACTGATAGTGAGCAG
CGGCTACAGCACCATAACCCGCATCACAACGGGCCGGTATCGGGAGGACAAAACACAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12031.64 Da        Isoelectric Point: 5.5075

>AT81468 WP_061278631.1 NZ_CP023525:c861830-861504 [Cedecea neteri]
MDSQQWGLMCSKTPCFGARLVQEGNRLHFLAERAGFTGDFSDDEALRLDQAFALIMKQLEQMLSSGELNPRQQQRVTLHH
IGLTCEADTLGSHGYIYITIYPSPAVTG

Download         Length: 327 bp

>AT81468 NZ_CP023525:c861830-861504 [Cedecea neteri]
ATGGATTCTCAACAATGGGGGCTGATGTGCAGTAAAACTCCGTGCTTTGGAGCCAGGCTGGTGCAGGAAGGCAACCGGCT
GCACTTTCTGGCTGAACGGGCAGGGTTTACTGGCGACTTCAGCGACGATGAAGCACTTCGCCTTGATCAGGCTTTTGCGC
TGATAATGAAACAGCTGGAACAGATGTTGTCATCTGGTGAGCTGAATCCCCGCCAGCAGCAACGCGTTACCCTGCATCAC
ATTGGGCTGACCTGCGAAGCCGATACGCTCGGTTCACACGGTTACATTTACATCACGATTTATCCCTCTCCGGCAGTCAC
CGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291DUG1

Antitoxin

Source ID Structure
AlphaFold DB A0A291DUD4

References