Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 841563..842360 Replicon chromosome
Accession NZ_CP023525
Organism Cedecea neteri strain FDAARGOS_392

Toxin (Protein)


Gene name KacT Uniprot ID A0A291DUM4
Locus tag CO704_RS04100 Protein ID WP_061278063.1
Coordinates 841836..842360 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A291DU29
Locus tag CO704_RS04095 Protein ID WP_061278061.1
Coordinates 841563..841832 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO704_RS04070 837755..838687 - 933 WP_061278052.1 LysR family transcriptional regulator -
CO704_RS04075 838808..839488 + 681 WP_061278054.1 nitroreductase -
CO704_RS04080 839538..839897 - 360 WP_061278056.1 hypothetical protein -
CO704_RS04085 840047..840352 - 306 WP_061278059.1 chaperone modulator CbpM -
CO704_RS04090 840352..841272 - 921 WP_061278091.1 curved DNA-binding protein -
CO704_RS04095 841563..841832 + 270 WP_061278061.1 DUF1778 domain-containing protein Antitoxin
CO704_RS04100 841836..842360 + 525 WP_061278063.1 GNAT family N-acetyltransferase Toxin
CO704_RS04105 842534..843118 + 585 WP_061278065.1 hypothetical protein -
CO704_RS04110 843406..843885 + 480 WP_061278067.1 Rrf2 family transcriptional regulator -
CO704_RS04115 843984..847136 - 3153 WP_061278070.1 multidrug efflux RND transporter permease subunit OqxB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(83-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19579.42 Da        Isoelectric Point: 8.2639

>T81467 WP_061278063.1 NZ_CP023525:841836-842360 [Cedecea neteri]
VADLMIELFSEQTAYDFCGFDCGEASLNAFLTEHFVRQHNGRFLRGYLLVTKDVNPKVLGYYTLSGSCFEKEALPSNTQK
RKIPYANVPSLTLGRLAIHKDLQGQEWGSTLVAHAMKVVYLASQAVGVHGIFVDAINDNAKRFYQKLGFIPLVGKNNNSL
FYPTRSIEKLFEHQ

Download         Length: 525 bp

>T81467 NZ_CP023525:841836-842360 [Cedecea neteri]
GTGGCTGACCTGATGATTGAATTATTTTCGGAACAAACTGCGTATGATTTTTGCGGCTTTGACTGCGGTGAAGCTTCTCT
GAATGCCTTTCTCACCGAGCACTTTGTCCGGCAGCATAATGGCCGTTTTTTACGCGGCTATCTTCTTGTGACAAAGGACG
TCAATCCTAAAGTGCTGGGTTACTACACTTTGTCCGGCAGCTGCTTTGAAAAAGAGGCGCTGCCGTCAAACACCCAGAAG
CGAAAAATCCCTTATGCCAATGTCCCCAGCTTGACGCTGGGGCGGCTGGCAATCCACAAAGATCTGCAGGGCCAGGAATG
GGGTTCAACGCTTGTGGCGCATGCGATGAAGGTGGTTTATTTAGCATCGCAGGCGGTGGGTGTTCATGGGATTTTTGTCG
ATGCTATTAACGATAATGCGAAGCGCTTTTATCAAAAATTAGGGTTTATTCCGCTGGTGGGGAAAAACAACAATTCGCTT
TTTTATCCGACCCGCTCGATTGAGAAATTATTTGAGCATCAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10198.70 Da        Isoelectric Point: 6.9832

>AT81467 WP_061278061.1 NZ_CP023525:841563-841832 [Cedecea neteri]
MSVLKKQRIDLRLSDDDKSMIEEAAAMSNQTITQFMIACASARAAEVIEQHRRLVLNEASWNRVMDAISNPPEPDDRLKR
AARRLKDME

Download         Length: 270 bp

>AT81467 NZ_CP023525:841563-841832 [Cedecea neteri]
ATGTCAGTTTTAAAAAAACAGCGCATCGACCTCAGATTGAGTGACGACGACAAAAGCATGATCGAAGAGGCGGCAGCCAT
GTCTAACCAGACGATCACTCAGTTTATGATTGCCTGTGCGTCTGCGCGCGCTGCGGAAGTTATCGAACAACATCGCCGCC
TGGTGCTGAATGAAGCATCGTGGAATCGTGTGATGGATGCTATCAGCAACCCGCCTGAACCGGATGACAGGCTCAAACGT
GCAGCAAGGCGTCTGAAAGACATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291DUM4

Antitoxin

Source ID Structure
AlphaFold DB A0A291DU29

References