Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 613786..614455 Replicon chromosome
Accession NZ_CP023525
Organism Cedecea neteri strain FDAARGOS_392

Toxin (Protein)


Gene name cptA Uniprot ID A0A291DTT3
Locus tag CO704_RS03085 Protein ID WP_061275672.1
Coordinates 614033..614455 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A089Q1B2
Locus tag CO704_RS03080 Protein ID WP_038479151.1
Coordinates 613786..614052 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO704_RS03060 610299..611027 - 729 WP_061275666.1 MurR/RpiR family transcriptional regulator -
CO704_RS03065 611070..611663 - 594 WP_061275668.1 HD domain-containing protein -
CO704_RS03070 611842..612495 + 654 WP_039297867.1 hemolysin III family protein -
CO704_RS03075 612553..613539 - 987 WP_061275670.1 tRNA-modifying protein YgfZ -
CO704_RS03080 613786..614052 + 267 WP_038479151.1 FAD assembly factor SdhE Antitoxin
CO704_RS03085 614033..614455 + 423 WP_061275672.1 protein YgfX Toxin
CO704_RS03090 614452..614973 - 522 WP_061275674.1 flavodoxin FldB -
CO704_RS03095 615076..615972 + 897 WP_061275676.1 site-specific tyrosine recombinase XerD -
CO704_RS03100 615999..616715 + 717 WP_061275678.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CO704_RS03105 616722..618455 + 1734 WP_039287484.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16560.53 Da        Isoelectric Point: 11.7122

>T81466 WP_061275672.1 NZ_CP023525:614033-614455 [Cedecea neteri]
VVLWQSDLRVSWRAQWMSLLLHGLVALFVLLMPWPMSYTLVWMLLLSLVVFDSVRSQRRIHARQGEIKLLADFRLRWQGR
DWDIVGNPWMIDSGVMLRLRRAGKHRCQHLWLAADSMDIVEWRDLRRLLTQQQASGSGQI

Download         Length: 423 bp

>T81466 NZ_CP023525:614033-614455 [Cedecea neteri]
GTGGTCCTGTGGCAATCTGATCTGCGGGTTTCATGGCGCGCGCAATGGATGTCATTACTCCTCCACGGCCTGGTGGCGCT
GTTTGTGCTGCTAATGCCGTGGCCGATGAGCTACACGCTGGTCTGGATGCTGCTGCTTTCCCTGGTGGTTTTCGACAGCG
TGCGCAGCCAGCGCCGTATTCACGCTCGCCAGGGTGAAATTAAACTGCTGGCGGACTTTCGCTTGCGCTGGCAGGGGCGT
GACTGGGATATCGTCGGAAATCCGTGGATGATTGACAGCGGAGTGATGCTAAGGCTGCGAAGGGCCGGAAAGCATCGCTG
CCAGCATCTTTGGCTGGCTGCTGACAGCATGGATATCGTTGAGTGGCGAGATTTACGCCGCCTGCTGACGCAGCAACAGG
CGAGCGGAAGCGGGCAGATTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10431.91 Da        Isoelectric Point: 5.6202

>AT81466 WP_038479151.1 NZ_CP023525:613786-614052 [Cedecea neteri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYETLSDSDKQLFVRLLESDDPDLFNWLMNHGKPADTELQRMVSLIQTRN
KERGPVAI

Download         Length: 267 bp

>AT81466 NZ_CP023525:613786-614052 [Cedecea neteri]
ATGGATATCAATAATAAAGCCCGAATTCACTGGGCATGCCGCCGTGGAATGCGCGAGCTCGATATTTCGATTATGCCGTT
CTTCGAACATGAATACGAAACGCTCAGCGACAGCGATAAGCAGCTGTTTGTTCGCCTGCTGGAGTCTGACGACCCAGACC
TGTTTAACTGGTTGATGAACCACGGTAAACCTGCGGATACGGAACTTCAGCGTATGGTTAGCCTGATTCAGACTCGGAAT
AAAGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291DTT3

Antitoxin

Source ID Structure
AlphaFold DB A0A089Q1B2

References