Detailed information of TA system TA081462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 74645..75161
• Replicon: plasmid unnamed
• Accession: NZ_CP023524
• Organism: Burkholderia gladioli pv. gladioli strain FDAARGOS_389

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CO712_RS35920
• Protein ID: WP_096753051.1
• Coordinates: 74645..74926 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: CO712_RS35925
• Protein ID: WP_096753052.1
• Coordinates: 74916..75161 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO712_RS35885	70469..72298	-	1830	WP_096753046.1	site-specific integrase	-
CO712_RS35890	72301..72639	-	339	WP_036057562.1	hypothetical protein	-
CO712_RS35900	73175..73417	-	243	WP_036057558.1	hypothetical protein	-
CO712_RS35905	73431..73715	-	285	WP_096753048.1	hypothetical protein	-
CO712_RS35910	73790..74002	-	213	WP_096753049.1	hypothetical protein	-
CO712_RS35915	74254..74496	-	243	WP_096753050.1	hypothetical protein	-
CO712_RS35920	74645..74926	-	282	WP_096753051.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CO712_RS35925	74916..75161	-	246	WP_096753052.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
CO712_RS35930	75426..76493	+	1068	WP_096753053.1	hypothetical protein	-
CO712_RS35935	76578..76862	-	285	WP_036057548.1	hypothetical protein	-
CO712_RS35940	76987..78306	-	1320	WP_096753054.1	replication protein O	-
CO712_RS35945	78637..79626	-	990	WP_096753132.1	ParB N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..151925	151925

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10916.56 Da
• Isoelectric Point: 9.6937

>T81462 WP_096753051.1 NZ_CP023524:c74926-74645 [Burkholderia gladioli pv. gladioli]
MRGKARAVRLTPLAEAGLEDIWAYTCEQYLGEFVAAFDRLARGEWVGGRAVRGPYWRYLVGFPALFYRETADVLNVTRVR
YQRMDVDRHLLRY

Nucleotide

• Length: 282 bp

>T81462 NZ_CP023524:c74926-74645 [Burkholderia gladioli pv. gladioli]
ATGCGGGGTAAGGCGCGGGCCGTGCGGCTGACGCCCTTGGCCGAGGCCGGCCTCGAGGACATCTGGGCCTACACCTGCGA
GCAGTACCTGGGCGAGTTCGTCGCTGCCTTCGACCGATTGGCGCGCGGCGAATGGGTCGGGGGCCGAGCCGTGCGGGGAC
CCTACTGGCGTTATCTGGTCGGCTTCCCTGCGCTGTTTTATCGAGAGACAGCCGACGTCTTGAATGTCACCCGTGTGCGG
TATCAGCGCATGGACGTGGATCGGCACCTGTTGCGGTATTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8599.66 Da
• Isoelectric Point: 7.2028

>AT81462 WP_096753052.1 NZ_CP023524:c75161-74916 [Burkholderia gladioli pv. gladioli]
MPRNTSISLGDHLTQFVDTQVASGRYGSASDVVRAGLRLLETQETELKALQEVLRAGEASGAPAAFDGQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT81462 NZ_CP023524:c75161-74916 [Burkholderia gladioli pv. gladioli]
ATGCCGCGGAACACATCGATCTCGCTGGGAGATCACTTGACTCAGTTCGTCGACACACAGGTCGCATCCGGCCGCTATGG
CTCGGCTAGTGACGTGGTGCGCGCCGGGCTGCGCCTGCTGGAGACGCAGGAGACCGAACTGAAGGCGCTGCAGGAGGTGT
TGCGCGCCGGTGAGGCGTCCGGCGCGCCGGCGGCGTTTGACGGCCAGGCGTTCCTCGCTCGCATGCGTGCGAAGCATGCG
GGGTAA