Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1251964..1252606 Replicon chromosome
Accession NZ_CP023523
Organism Burkholderia gladioli pv. gladioli strain FDAARGOS_389

Toxin (Protein)


Gene name vapC Uniprot ID A0A0M2Q595
Locus tag CO712_RS24325 Protein ID WP_046582149.1
Coordinates 1251964..1252386 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0M2Q1H9
Locus tag CO712_RS24330 Protein ID WP_046582289.1
Coordinates 1252373..1252606 (-) Length 78 a.a.

Genomic Context

CO712_RS24305CO712_RS24310CO712_RS24320CO712_RS24340CO712_RS24345CO712_RS24315CO712_RS24325CO712_RS24330CO712_RS24335
Location: 1247765..1249138 (1374 bp)
Type: Others
Protein ID: WP_046582154.1
Location: 1249141..1250223 (1083 bp)
Type: Others
Protein ID: WP_046582152.1
Location: 1251163..1251843 (681 bp)
Type: Others
Protein ID: WP_013690720.1
Location: 1253535..1254569 (1035 bp)
Type: Others
Protein ID: WP_046582145.1
Location: 1254781..1255917 (1137 bp)
Type: Others
Protein ID: WP_046582143.1
Location: 1250243..1251013 (771 bp)
Type: Others
Protein ID: WP_046582151.1
Location: 1251964..1252386 (423 bp)
Type: Toxin
Protein ID: WP_046582149.1
Location: 1252373..1252606 (234 bp)
Type: Antitoxin
Protein ID: WP_046582289.1
Location: 1252940..1253332 (393 bp)
Type: Others
Protein ID: WP_096751447.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CO712_RS243051247765..1249138+1374WP_046582154.1L-fucose:H+ symporter permease-
CO712_RS243101249141..1250223+1083WP_046582152.1aldose 1-epimerase family protein-
CO712_RS243151250243..1251013-771WP_046582151.1DNA-binding transcriptional repressor DeoR-
CO712_RS243201251163..1251843+681WP_013690720.1deoxyribose-phosphate aldolase-
CO712_RS243251251964..1252386-423WP_046582149.1type II toxin-antitoxin system VapC family toxinToxin
CO712_RS243301252373..1252606-234WP_046582289.1DNA-binding proteinAntitoxin
CO712_RS243351252940..1253332-393WP_096751447.1hypothetical protein-
CO712_RS243401253535..1254569+1035WP_046582145.1flavodoxin family protein-
CO712_RS243451254781..1255917+1137WP_046582143.1glutathione-independent formaldehyde dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1244186..12526068420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15618.94 Da        Isoelectric Point: 9.9428

>T81459 WP_046582149.1 NZ_CP023523:c1252386-1251964 [Burkholderia gladioli pv. gladioli]
MYLIDANVVSEVRKRDRADKGVMAFFRQAARDDAGLYLSVVTVGELRRGVEIIRHRGDKSQATRLANWLDGVLREFAANI
LVVDKEIGQMWGYLRVPRSEHSLDKVIAATALIHDLTVVTRNVDDFAGTGARVLNPFKGP

Download         Length: 423 bp

>T81459 NZ_CP023523:c1252386-1251964 [Burkholderia gladioli pv. gladioli]
ATGTATTTGATTGACGCCAATGTGGTCAGCGAAGTCCGGAAACGGGATCGTGCGGACAAGGGCGTGATGGCCTTCTTTCG
CCAGGCGGCCCGCGACGATGCCGGCCTGTACCTGTCGGTGGTGACGGTGGGCGAACTGCGGCGAGGTGTGGAAATCATCC
GTCACCGTGGCGACAAATCCCAGGCAACGCGTCTCGCGAACTGGCTCGATGGCGTGCTCCGGGAGTTTGCCGCGAACATT
CTCGTGGTGGACAAGGAGATCGGGCAGATGTGGGGCTACCTGCGTGTACCTCGCTCGGAACACTCGCTGGATAAGGTGAT
CGCCGCCACGGCCTTGATTCACGATCTGACCGTGGTGACGCGCAACGTGGACGATTTCGCCGGAACCGGTGCCCGTGTGC
TGAACCCGTTCAAGGGCCCATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8514.60 Da        Isoelectric Point: 5.0618

>AT81459 WP_046582289.1 NZ_CP023523:c1252606-1252373 [Burkholderia gladioli pv. gladioli]
MANLLVRNVDEMLVQILRERAAAHGHSAEAEHREILARALREPQRKTFAQALMGMPNVGSDADFARVDDGEAANVFD

Download         Length: 234 bp

>AT81459 NZ_CP023523:c1252606-1252373 [Burkholderia gladioli pv. gladioli]
ATGGCGAATCTTCTGGTGAGAAACGTGGACGAAATGCTTGTTCAAATCTTGCGCGAGCGGGCTGCCGCTCACGGGCACAG
CGCGGAAGCCGAGCATCGTGAAATCCTGGCAAGGGCGCTGCGCGAGCCGCAGCGCAAGACATTCGCGCAAGCGCTGATGG
GCATGCCGAACGTCGGTAGCGATGCCGATTTTGCGCGCGTGGACGATGGCGAGGCGGCGAATGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0M2Q595

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0M2Q1H9

References