Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1251964..1252606 Replicon chromosome
Accession NZ_CP023523
Organism Burkholderia gladioli pv. gladioli strain FDAARGOS_389

Toxin (Protein)


Gene name vapC Uniprot ID A0A0M2Q595
Locus tag CO712_RS24325 Protein ID WP_046582149.1
Coordinates 1251964..1252386 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0M2Q1H9
Locus tag CO712_RS24330 Protein ID WP_046582289.1
Coordinates 1252373..1252606 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO712_RS24305 1247765..1249138 + 1374 WP_046582154.1 L-fucose:H+ symporter permease -
CO712_RS24310 1249141..1250223 + 1083 WP_046582152.1 aldose 1-epimerase family protein -
CO712_RS24315 1250243..1251013 - 771 WP_046582151.1 DNA-binding transcriptional repressor DeoR -
CO712_RS24320 1251163..1251843 + 681 WP_013690720.1 deoxyribose-phosphate aldolase -
CO712_RS24325 1251964..1252386 - 423 WP_046582149.1 type II toxin-antitoxin system VapC family toxin Toxin
CO712_RS24330 1252373..1252606 - 234 WP_046582289.1 DNA-binding protein Antitoxin
CO712_RS24335 1252940..1253332 - 393 WP_096751447.1 hypothetical protein -
CO712_RS24340 1253535..1254569 + 1035 WP_046582145.1 flavodoxin family protein -
CO712_RS24345 1254781..1255917 + 1137 WP_046582143.1 glutathione-independent formaldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1244186..1252606 8420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15618.94 Da        Isoelectric Point: 9.9428

>T81459 WP_046582149.1 NZ_CP023523:c1252386-1251964 [Burkholderia gladioli pv. gladioli]
MYLIDANVVSEVRKRDRADKGVMAFFRQAARDDAGLYLSVVTVGELRRGVEIIRHRGDKSQATRLANWLDGVLREFAANI
LVVDKEIGQMWGYLRVPRSEHSLDKVIAATALIHDLTVVTRNVDDFAGTGARVLNPFKGP

Download         Length: 423 bp

>T81459 NZ_CP023523:c1252386-1251964 [Burkholderia gladioli pv. gladioli]
ATGTATTTGATTGACGCCAATGTGGTCAGCGAAGTCCGGAAACGGGATCGTGCGGACAAGGGCGTGATGGCCTTCTTTCG
CCAGGCGGCCCGCGACGATGCCGGCCTGTACCTGTCGGTGGTGACGGTGGGCGAACTGCGGCGAGGTGTGGAAATCATCC
GTCACCGTGGCGACAAATCCCAGGCAACGCGTCTCGCGAACTGGCTCGATGGCGTGCTCCGGGAGTTTGCCGCGAACATT
CTCGTGGTGGACAAGGAGATCGGGCAGATGTGGGGCTACCTGCGTGTACCTCGCTCGGAACACTCGCTGGATAAGGTGAT
CGCCGCCACGGCCTTGATTCACGATCTGACCGTGGTGACGCGCAACGTGGACGATTTCGCCGGAACCGGTGCCCGTGTGC
TGAACCCGTTCAAGGGCCCATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8514.60 Da        Isoelectric Point: 5.0618

>AT81459 WP_046582289.1 NZ_CP023523:c1252606-1252373 [Burkholderia gladioli pv. gladioli]
MANLLVRNVDEMLVQILRERAAAHGHSAEAEHREILARALREPQRKTFAQALMGMPNVGSDADFARVDDGEAANVFD

Download         Length: 234 bp

>AT81459 NZ_CP023523:c1252606-1252373 [Burkholderia gladioli pv. gladioli]
ATGGCGAATCTTCTGGTGAGAAACGTGGACGAAATGCTTGTTCAAATCTTGCGCGAGCGGGCTGCCGCTCACGGGCACAG
CGCGGAAGCCGAGCATCGTGAAATCCTGGCAAGGGCGCTGCGCGAGCCGCAGCGCAAGACATTCGCGCAAGCGCTGATGG
GCATGCCGAACGTCGGTAGCGATGCCGATTTTGCGCGCGTGGACGATGGCGAGGCGGCGAATGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2Q595

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2Q1H9

References