Detailed information of TA system TA081447

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 255505..256160
• Replicon: chromosome
• Accession: NZ_CP023521
• Organism: Burkholderia cepacia strain FDAARGOS_388

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: U2HGC0
• Locus tag: CO711_RS25825
• Protein ID: WP_021158162.1
• Coordinates: 255741..256160 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U2HMP5
• Locus tag: CO711_RS25820
• Protein ID: WP_021158161.1
• Coordinates: 255505..255744 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO711_RS25795	250790..251185	-	396	WP_027789497.1	type II toxin-antitoxin system VapC family toxin	-
CO711_RS25800	251182..251421	-	240	WP_011659184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
CO711_RS25805	251510..252193	-	684	WP_027789496.1	Fe2+-dependent dioxygenase	-
CO711_RS25810	252190..252945	-	756	WP_027789495.1	sel1 repeat family protein	-
CO711_RS25815	252949..255195	-	2247	WP_027789494.1	TonB-dependent siderophore receptor	-
CO711_RS25820	255505..255744	+	240	WP_021158161.1	antitoxin VapB	Antitoxin
CO711_RS25825	255741..256160	+	420	WP_021158162.1	type II toxin-antitoxin system VapC family toxin	Toxin
CO711_RS25830	256296..257591	-	1296	WP_027789492.1	aspartate carbamoyltransferase	-
CO711_RS25835	257825..257959	+	135	WP_021158165.1	entericidin A/B family lipoprotein	-
CO711_RS25840	258063..258611	-	549	WP_027789491.1	hypothetical protein	-
CO711_RS25845	258796..259749	-	954	WP_027789490.1	DMT family transporter	-
CO711_RS25850	260009..260803	-	795	WP_027789489.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15212.57 Da
• Isoelectric Point: 5.9052

>T81447 WP_021158162.1 NZ_CP023521:255741-256160 [Burkholderia cepacia]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAAISLAEIRLGVAVLPEGRRREWLHQSIEQRVLPLFRGRILPFDD
AASKAYASLRARARAAGVAIAPSDGFIAGTAEANGLIVATRDVTPFEAMGIRVIDPWAR

Nucleotide

• Length: 420 bp

>T81447 NZ_CP023521:255741-256160 [Burkholderia cepacia]
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCGCTACGACGCGAGCCGAACGCGGCCGTGATCGAGTGGCTCGATGC
CCAGAATGTCGAAACCTTGTTTCTGGCTGCGATCAGTCTCGCGGAAATACGATTGGGCGTGGCTGTATTGCCGGAAGGAC
GCCGGCGAGAGTGGCTGCATCAGAGCATCGAGCAGCGCGTGCTGCCATTGTTTCGCGGACGAATCCTGCCATTCGACGAT
GCTGCGAGCAAAGCGTATGCGAGCCTTCGCGCACGCGCTCGTGCCGCAGGTGTCGCAATTGCACCATCCGATGGTTTTAT
CGCCGGCACGGCCGAAGCGAACGGCCTGATCGTCGCCACGCGCGATGTCACGCCGTTCGAGGCAATGGGAATTCGCGTAA
TCGACCCGTGGGCGCGCTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8629.79 Da
• Isoelectric Point: 5.6643

>AT81447 WP_021158161.1 NZ_CP023521:255505-255744 [Burkholderia cepacia]
MPVITVRNLSDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTMLAAIGQEAGGFDFDAQRDKTPADPMSFE

Nucleotide

• Length: 240 bp

>AT81447 NZ_CP023521:255505-255744 [Burkholderia cepacia]
ATGCCGGTGATCACCGTCCGAAATCTGTCCGATGAAGTGCATCGAGCACTTCGCATTCGCGCGGCCCAACATGGGCGCAG
CACCGAAGCCGAGGTGCGCGACATTCTCGAACAGGCCGTTCTTCCGGGCGGGCGGCTCAAGCTGGGAACGATGCTGGCGG
CAATCGGGCAGGAGGCCGGCGGATTCGATTTCGACGCCCAGCGCGACAAGACGCCTGCCGATCCGATGAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: U2HGC0

Antitoxin

• AlphaFold DB: U2HMP5