Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parE-vagC/RelE-VagC
Location 1882093..1882750 Replicon chromosome
Accession NZ_CP023518
Organism Burkholderia cepacia strain FDAARGOS_388

Toxin (Protein)


Gene name parE Uniprot ID A0A1Z3YPK5
Locus tag CO711_RS09100 Protein ID WP_027788679.1
Coordinates 1882093..1882377 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1Z3YWA1
Locus tag CO711_RS09105 Protein ID WP_027788678.1
Coordinates 1882514..1882750 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO711_RS09075 1877262..1878293 + 1032 WP_027788682.1 helix-turn-helix domain-containing protein -
CO711_RS09085 1878492..1879634 - 1143 WP_049097352.1 ADP-heptose--LPS heptosyltransferase -
CO711_RS09090 1879631..1881334 - 1704 WP_027788681.1 thiamine pyrophosphate-binding protein -
CO711_RS09095 1881635..1882096 + 462 WP_027788680.1 hypothetical protein -
CO711_RS09100 1882093..1882377 + 285 WP_027788679.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CO711_RS09105 1882514..1882750 + 237 WP_027788678.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CO711_RS09110 1882750..1883151 + 402 WP_027788677.1 type II toxin-antitoxin system VapC family toxin -
CO711_RS09115 1883218..1884606 - 1389 WP_027788676.1 L-serine ammonia-lyase -
CO711_RS09120 1884637..1885773 - 1137 WP_027788675.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10794.40 Da        Isoelectric Point: 5.7133

>T81443 WP_027788679.1 NZ_CP023518:1882093-1882377 [Burkholderia cepacia]
MTLALHWNPKAYEDRAAIMDYIGEDDPQAAIELDELLEQRAATLPARAELYRQGRVAGTRELVVAPNYVLVYRIRPAEGI
VEILRVLHARRQWP

Download         Length: 285 bp

>T81443 NZ_CP023518:1882093-1882377 [Burkholderia cepacia]
TTGACCCTCGCGCTGCACTGGAATCCGAAGGCGTACGAGGATCGCGCCGCGATCATGGACTACATCGGCGAGGACGACCC
GCAGGCCGCAATCGAACTCGACGAACTGCTGGAACAAAGGGCCGCCACGTTGCCGGCCCGTGCAGAGCTGTATCGGCAAG
GGCGAGTGGCCGGCACGCGCGAACTGGTGGTCGCGCCGAACTACGTGCTCGTGTATCGCATCAGACCGGCTGAGGGGATC
GTCGAGATCCTCCGCGTGCTGCATGCGCGACGGCAGTGGCCGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9144.34 Da        Isoelectric Point: 5.1974

>AT81443 WP_027788678.1 NZ_CP023518:1882514-1882750 [Burkholderia cepacia]
MHTTKVFRNGNSQAVRIPADLAYERNDIELEIERIGDEIRIRPMRRPLTRVLEKFAKFGPDFMAEGRGDQEQADREEL

Download         Length: 237 bp

>AT81443 NZ_CP023518:1882514-1882750 [Burkholderia cepacia]
ATGCACACGACGAAGGTATTTCGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCCGACCTCGCCTATGAGCGTAACGA
TATCGAACTGGAAATCGAGCGTATCGGTGACGAAATCCGTATTCGACCGATGCGGCGGCCGTTGACCCGCGTACTCGAGA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAAGGGCGCGGCGACCAGGAGCAGGCCGATCGCGAGGAGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z3YPK5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3YWA1

References