Detailed information of TA system TA081440

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 1915552..1916081
• Replicon: chromosome
• Accession: NZ_CP023515
• Organism: Enterococcus sp. FDAARGOS_375

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C9B8W9
• Locus tag: CO692_RS10290
• Protein ID: WP_002294198.1
• Coordinates: 1915815..1916081 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CO692_RS10285
• Protein ID: WP_086293915.1
• Coordinates: 1915552..1915815 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO692_RS10270	1911126..1912388	-	1263	WP_096742192.1	glycoside hydrolase family 27 protein	-
CO692_RS10275	1912509..1913408	+	900	WP_096742193.1	AraC family transcriptional regulator	-
CO692_RS10280	1913458..1915398	+	1941	WP_096742194.1	glycoside hydrolase family 127 protein	-
CO692_RS10285	1915552..1915815	+	264	WP_086293915.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CO692_RS10290	1915815..1916081	+	267	WP_002294198.1	Txe/YoeB family addiction module toxin	Toxin
CO692_RS10295	1916275..1919106	+	2832	WP_096742195.1	discoidin domain-containing protein	-
CO692_RS10300	1919238..1919891	-	654	WP_170920125.1	ABC transporter permease	-
CO692_RS10305	1919905..1920825	-	921	WP_086293917.1	osmoprotectant ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (22-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (5-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10646.11 Da
• Isoelectric Point: 9.9931

>T81440 WP_002294198.1 NZ_CP023515:1915815-1916081 [Enterococcus sp. FDAARGOS_375]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Nucleotide

• Length: 267 bp

>T81440 NZ_CP023515:1915815-1916081 [Enterococcus sp. FDAARGOS_375]
ATGAGTAACTATACAGTCGCAATTAAAAACTCTGCGAAAGTGGATCTAAGGAAAATCAAACAATCGAATTTAAAGAAACA
GTTTGAAGAAGTGATTCAGACCTTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATATTCACGTAGGCTGAATAGGCAACATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCATGGACACATTATGAATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10002.99 Da
• Isoelectric Point: 4.0542

>AT81440 WP_086293915.1 NZ_CP023515:1915552-1915815 [Enterococcus sp. FDAARGOS_375]
MANTTMNPSTARKNFYQLLKDVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTDID
DIDWEAL

Nucleotide

• Length: 264 bp

>AT81440 NZ_CP023515:1915552-1915815 [Enterococcus sp. FDAARGOS_375]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGCAAAAATTTTTATCAGTTATTGAAAGATGTAAATGAAAACCATAC
TGAAATTGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTGTTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTCTAGACAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGGATATTGAT
GATATTGATTGGGAAGCTCTTTGA

Structures

Toxin

• AlphaFold DB: A0A829FMA0