Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 390425..391059 Replicon chromosome
Accession NZ_CP023515
Organism Enterococcus sp. FDAARGOS_375

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CO692_RS02805 Protein ID WP_096741485.1
Coordinates 390425..390775 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CO692_RS02810 Protein ID WP_096742851.1
Coordinates 390769..391059 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO692_RS02780 386075..387436 - 1362 WP_096741480.1 citrate transporter -
CO692_RS02785 387786..388709 - 924 WP_096741481.1 peptide-methionine (S)-S-oxide reductase MsrA -
CO692_RS02795 389036..389581 - 546 WP_185932311.1 cysteine hydrolase -
CO692_RS02800 389684..390109 + 426 WP_096741484.1 AsnC family transcriptional regulator -
CO692_RS02805 390425..390775 - 351 WP_096741485.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CO692_RS02810 390769..391059 - 291 WP_096742851.1 PbsX family transcriptional regulator Antitoxin
CO692_RS17560 391319..391486 - 168 WP_123906404.1 hypothetical protein -
CO692_RS17565 391833..391931 - 99 WP_123906405.1 type I toxin-antitoxin system Fst family toxin -
CO692_RS02815 391968..392777 - 810 WP_096741486.1 type I methionyl aminopeptidase -
CO692_RS02820 392820..393557 - 738 WP_096741487.1 tRNA pseudouridine(38-40) synthase TruA -
CO692_RS02825 393624..394103 - 480 WP_077452817.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
CO692_RS02830 394477..395781 + 1305 WP_096741488.1 trypsin-like peptidase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

Antitoxin PemI-like

(13-96)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13108.12 Da        Isoelectric Point: 8.0511

>T81439 WP_096741485.1 NZ_CP023515:c390775-390425 [Enterococcus sp. FDAARGOS_375]
MVRKPRQGDILLLDTAPRSGHEQTGKRPYIVLSHDMIADYSNVATVAPISSTSRNYPLYVSIDPDYGMKTTGKVLLDQLT
TIDYEARACVFLEKAHEHLVDELLMKVRTVFQKVSK

Download         Length: 351 bp

>T81439 NZ_CP023515:c390775-390425 [Enterococcus sp. FDAARGOS_375]
ATGGTAAGAAAACCTAGACAAGGGGATATTTTGTTATTGGATACAGCTCCTCGTTCTGGACATGAACAAACGGGAAAAAG
ACCCTATATTGTTTTAAGTCATGACATGATTGCAGATTATAGTAACGTTGCCACCGTTGCTCCGATTTCTAGTACAAGTA
GAAACTATCCGTTATATGTAAGTATTGATCCAGACTATGGAATGAAGACAACAGGAAAAGTATTGTTGGATCAATTAACG
ACAATTGATTATGAAGCCAGAGCGTGTGTTTTTTTGGAAAAAGCGCATGAGCACTTGGTTGATGAGTTATTGATGAAAGT
TAGAACAGTATTTCAAAAAGTAAGTAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11305.01 Da        Isoelectric Point: 4.9389

>AT81439 WP_096742851.1 NZ_CP023515:c391059-390769 [Enterococcus sp. FDAARGOS_375]
MYIQKEVLLMEMLPIKKWGNSNGLRLPKYIMEYLGIHTDDKVKIIQEEVNGHKRLIIEAANLENELTIEELFENYTAERN
HVEIQHLGEAVGNEKW

Download         Length: 291 bp

>AT81439 NZ_CP023515:c391059-390769 [Enterococcus sp. FDAARGOS_375]
ATGTATATACAGAAAGAGGTGTTGCTCATGGAAATGTTACCTATAAAAAAATGGGGCAATAGTAACGGTCTTAGATTGCC
AAAGTACATTATGGAGTATCTTGGCATTCATACTGATGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGACATAAAC
GGCTAATCATCGAAGCAGCAAATTTAGAAAACGAGTTAACGATTGAAGAGTTATTTGAAAATTACACTGCTGAGAGAAAT
CATGTGGAAATTCAACATTTAGGTGAAGCAGTAGGGAATGAAAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References