Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 669194..670437 Replicon chromosome
Accession NZ_CP023507
Organism Streptococcus oralis strain FDAARGOS_367

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag CO686_RS03325 Protein ID WP_096753501.1
Coordinates 669670..670437 (+) Length 256 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag CO686_RS03320 Protein ID WP_096753500.1
Coordinates 669194..669670 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO686_RS03280 665451..665735 + 285 WP_000969635.1 hypothetical protein -
CO686_RS03285 665749..666045 + 297 WP_096753495.1 hypothetical protein -
CO686_RS03290 666059..666256 - 198 WP_001842085.1 hypothetical protein -
CO686_RS03295 666416..667057 + 642 WP_000933084.1 hypothetical protein -
CO686_RS03300 667067..668152 + 1086 WP_096753496.1 toprim domain-containing protein -
CO686_RS03305 668203..668436 + 234 WP_096753497.1 hypothetical protein -
CO686_RS03310 668433..668816 + 384 WP_096753498.1 chemotaxis protein -
CO686_RS03315 668854..669126 + 273 WP_096753499.1 hypothetical protein -
CO686_RS03320 669194..669670 + 477 WP_096753500.1 helix-turn-helix domain-containing protein Antitoxin
CO686_RS03325 669670..670437 + 768 WP_096753501.1 zeta toxin family protein Toxin
CO686_RS03330 670472..672091 + 1620 WP_096753502.1 DUF4297 domain-containing protein -
CO686_RS03335 672078..672617 + 540 WP_008809290.1 hypothetical protein -
CO686_RS03340 672607..675246 + 2640 WP_096753503.1 SMC family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 663640..733286 69646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29188.12 Da        Isoelectric Point: 6.4153

>T81436 WP_096753501.1 NZ_CP023507:669670-670437 [Streptococcus oralis]
MEIQDYTDSAFKHALARNVRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTVDVPKKTAQLLKNKGHEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNSRQLEELAIFERIQIYQRDRSCVYDSKENLTSAADVLQELLFGEWSQVEKEML
QVEEEILETLCNRTE

Download         Length: 768 bp

>T81436 NZ_CP023507:669670-670437 [Streptococcus oralis]
ATGGAAATCCAAGATTATACCGATAGTGCATTCAAACATGCTTTAGCGCGGAACGTTCGCTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAGCCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCTGGTAAAACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATCGAGGGAACTCTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGACATGAAGTACAATTAGCCTTAATTGCGACAAAACCTAAGCTGTCCTATCTGAGCACTCTTATCCGATATGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TTCACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATCTAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAGGTAGAGAAAGAGATGTTG
CAGGTGGAGGAAGAGATTTTAGAAACCTTGTGTAATCGTACAGAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18271.72 Da        Isoelectric Point: 4.4735

>AT81436 WP_096753500.1 NZ_CP023507:669194-669670 [Streptococcus oralis]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTDLIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
ILKERGANLLSRLYRYQDSQGINIDDESNPWILMSDDLSNLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT81436 NZ_CP023507:669194-669670 [Streptococcus oralis]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGATCTAATAGATATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATCGTAGGAGAAGACAAAATGCTCAATCCTGTTGAAGATTATGAACTGACTTTAAAAATTGAA
ATTCTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGCTATCAAGATAGTCAGGGAATTAACATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTAACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References