Detailed information of TA system TA081435

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3376120..3376937
• Replicon: chromosome
• Accession: NZ_CP023505
• Organism: Morganella morganii strain FDAARGOS_365

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: CO693_RS16365
• Protein ID: WP_015422406.1
• Coordinates: 3376120..3376626 (-)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: CO693_RS16370
• Protein ID: WP_032097998.1
• Coordinates: 3376629..3376937 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO693_RS16335	3371479..3372102	-	624	WP_004236525.1	thiol:disulfide interchange protein DsbA	-
CO693_RS16340	3372121..3373116	-	996	WP_004236526.1	serine/threonine protein kinase	-
CO693_RS16345	3373116..3373385	-	270	WP_004240741.1	YihD family protein	-
CO693_RS16350	3373588..3374703	+	1116	WP_096747622.1	molybdenum cofactor guanylyltransferase MobA	-
CO693_RS16355	3374918..3375220	+	303	WP_004240743.1	exported protein precursor	-
CO693_RS16360	3375348..3375869	+	522	WP_015422407.1	isopentenyl-diphosphate Delta-isomerase	-
CO693_RS20010	3375866..3376112	+	247	Protein_3169	hypothetical protein	-
CO693_RS16365	3376120..3376626	-	507	WP_015422406.1	GNAT family N-acetyltransferase	Toxin
CO693_RS16370	3376629..3376937	-	309	WP_032097998.1	DUF1778 domain-containing protein	Antitoxin
CO693_RS16375	3377069..3378421	-	1353	WP_046024838.1	glutathione-disulfide reductase	-
CO693_RS16380	3378491..3379333	-	843	WP_024473610.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
CO693_RS16385	3379523..3379912	+	390	WP_004236536.1	DUF1090 domain-containing protein	-
CO693_RS16390	3380324..3381316	+	993	WP_046024794.1	inner membrane protein YhjD	-
CO693_RS16395	3381424..3381630	+	207	WP_004236540.1	4-oxalocrotonate tautomerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-94)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18565.43 Da
• Isoelectric Point: 9.9508

>T81435 WP_015422406.1 NZ_CP023505:c3376626-3376120 [Morganella morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE

Nucleotide

• Length: 507 bp

>T81435 NZ_CP023505:c3376626-3376120 [Morganella morganii]
TTGAACTTAACGGCACCGGAACCCTTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCA
TTGGCTGAAAACCCGCGCATTGCAAAATCAGCAATCCGGCGCTTCACGGACATTTGTCGTCTGCCACCATAACCGGATAA
TGGCCTATTATGCATTATCGACAGGCGTTATTACCTGTTCACAGGCGGCGGGTCGTTTCAGACGTAATATGCCCCCGGAA
ATTCCGGTTATCCTGCCGGGACGTCTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGA
TGCCGCACTGCGGGTCTTGCAGGCGGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCA
GACGTTTTTATGAGCATACCGGTTTTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAG
CTGGCAACCGGCATCTATTCTGAATAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11469.12 Da
• Isoelectric Point: 8.6397

>AT81435 WP_032097998.1 NZ_CP023505:c3376937-3376629 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLAKAPWEK

Nucleotide

• Length: 309 bp

>AT81435 NZ_CP023505:c3376937-3376629 [Morganella morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGGCGAAGGCGCCGTGGGAGAAGTAA