Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4308619..4309217 Replicon chromosome
Accession NZ_CP023504
Organism Citrobacter werkmanii strain FDAARGOS_364

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CO701_RS21290 Protein ID WP_096758860.1
Coordinates 4308619..4308993 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CO701_RS21295 Protein ID WP_170975228.1
Coordinates 4308993..4309217 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO701_RS21275 4306123..4307025 + 903 WP_096758857.1 formate dehydrogenase O subunit beta -
CO701_RS21280 4307022..4307657 + 636 WP_096758858.1 formate dehydrogenase cytochrome b556 subunit -
CO701_RS21285 4307654..4308583 + 930 WP_096758859.1 formate dehydrogenase accessory protein FdhE -
CO701_RS21290 4308619..4308993 - 375 WP_096758860.1 type II toxin-antitoxin system VapC family toxin Toxin
CO701_RS21295 4308993..4309217 - 225 WP_170975228.1 ribbon-helix-helix domain-containing protein Antitoxin
CO701_RS21300 4309440..4310354 + 915 WP_096758862.1 alpha/beta hydrolase -
CO701_RS21305 4310394..4311335 - 942 WP_153064726.1 fatty acid biosynthesis protein FabY -
CO701_RS21310 4311380..4311817 - 438 WP_096758864.1 D-tyrosyl-tRNA(Tyr) deacylase -
CO701_RS21315 4311820..4312686 - 867 WP_096758865.1 virulence factor BrkB family protein -
CO701_RS21320 4312680..4313279 - 600 WP_096758866.1 glucose-1-phosphatase -
CO701_RS21325 4313385..4314188 - 804 WP_096758867.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-41)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13853.08 Da        Isoelectric Point: 9.8625

>T81431 WP_096758860.1 NZ_CP023504:c4308993-4308619 [Citrobacter werkmanii]
MVNGSALFDTNILIDLFSGRAEAKYAIETWPPQNAISLITWMEVMVGAKKYRQESRTRVALSAFNIIGVSQDIAERSVRL
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGIPGVITPYQV

Download         Length: 375 bp

>T81431 NZ_CP023504:c4308993-4308619 [Citrobacter werkmanii]
ATGGTTAACGGGTCAGCGCTTTTTGATACCAATATCCTCATCGATCTGTTTAGCGGACGGGCTGAAGCAAAATATGCGAT
AGAAACATGGCCGCCGCAGAATGCCATTAGCCTTATCACGTGGATGGAGGTAATGGTAGGCGCAAAAAAGTATCGTCAGG
AATCCCGTACACGTGTTGCGTTGAGTGCATTTAACATTATCGGCGTGTCGCAGGATATTGCGGAAAGAAGCGTTCGCCTC
AGGCAGGAATATGGGATGAAATTGCCGGATGCGATTATTCTGGCAACTGCGCAGATACATCGCCTTACGCTGGTCACGCG
TAATACCAAGGATTTTGCAGGAATCCCTGGGGTAATCACGCCATATCAAGTGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8701.75 Da        Isoelectric Point: 4.2075

>AT81431 WP_170975228.1 NZ_CP023504:c4309217-4308993 [Citrobacter werkmanii]
MGRILLDLSDEVIQRLDDLKVQRNLPRAELLREAVEQYLERQDNAETTISGALGLWQGCEEDGVEYQRKLREEW

Download         Length: 225 bp

>AT81431 NZ_CP023504:c4309217-4308993 [Citrobacter werkmanii]
ATGGGCAGAATTTTACTCGATTTGTCTGATGAGGTGATTCAACGGCTTGACGATCTCAAGGTGCAGCGCAATCTTCCCCG
TGCTGAATTACTACGGGAAGCGGTTGAGCAGTATCTGGAAAGGCAGGATAACGCTGAGACCACTATTTCTGGCGCCCTTG
GTCTATGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGCAAGCTTCGTGAGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References