Detailed information of TA system TA081429

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4056540..4057075
• Replicon: chromosome
• Accession: NZ_CP023504
• Organism: Citrobacter werkmanii strain FDAARGOS_364

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CO701_RS20105
• Protein ID: WP_096758666.1
• Coordinates: 4056788..4057075 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4BKM9
• Locus tag: CO701_RS20100
• Protein ID: WP_006688247.1
• Coordinates: 4056540..4056791 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO701_RS20070	4051553..4052401	+	849	WP_135912711.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
CO701_RS20075	4052398..4053156	+	759	WP_096758661.1	phosphonate C-P lyase system protein PhnK	-
CO701_RS20080	4053264..4053944	+	681	WP_096758662.1	phosphonate C-P lyase system protein PhnL	-
CO701_RS20085	4053941..4055077	+	1137	WP_096758663.1	alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase	-
CO701_RS20090	4055080..4055625	+	546	WP_096758664.1	ribose 1,5-bisphosphokinase	-
CO701_RS20095	4055698..4056456	+	759	WP_096758665.1	phosphonate metabolism protein PhnP	-
CO701_RS20100	4056540..4056791	+	252	WP_006688247.1	plasmid stabilization protein	Antitoxin
CO701_RS20105	4056788..4057075	+	288	WP_096758666.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CO701_RS20110	4057072..4057401	-	330	WP_096758667.1	hypothetical protein	-
CO701_RS20115	4057470..4059734	-	2265	WP_096758668.1	hybrid sensor histidine kinase/response regulator	-
CO701_RS20125	4059849..4061372	+	1524	WP_096758669.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11092.00 Da
• Isoelectric Point: 10.0828

>T81429 WP_096758666.1 NZ_CP023504:4056788-4057075 [Citrobacter werkmanii]
MSYTVKFREDALKEWQKLDKTIQQQFAKKLKKCCENPHVPSEKLGGIKDCYKIKLRTSGFRLVYQVIDETLVIAVVAVGK
RERSEVYNLASERLR

Nucleotide

• Length: 288 bp

>T81429 NZ_CP023504:4056788-4057075 [Citrobacter werkmanii]
ATGAGTTATACGGTAAAGTTCAGGGAAGATGCGCTGAAAGAATGGCAAAAACTGGATAAAACCATTCAGCAGCAGTTTGC
CAAAAAACTCAAGAAATGCTGTGAAAATCCGCATGTCCCCTCCGAGAAGCTCGGGGGAATAAAAGATTGCTATAAAATCA
AACTACGCACTTCAGGGTTCCGTCTTGTTTATCAAGTTATTGACGAAACACTGGTCATCGCTGTCGTTGCCGTCGGTAAA
CGCGAGCGTAGTGAAGTTTATAATCTTGCCAGCGAAAGACTACGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9215.53 Da
• Isoelectric Point: 4.2965

>AT81429 WP_006688247.1 NZ_CP023504:4056540-4056791 [Citrobacter werkmanii]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT81429 NZ_CP023504:4056540-4056791 [Citrobacter werkmanii]
ATGCCACATATCATTTTAAGCGACACCACCGCCAGCGTGAGTGAGCTAAAAAAGAACCCGATGGCGACTGTTAGCGCAGG
GGATGGGTTTCCGGTCGCAATCCTGAACCGTAACCAGCCCGCCTTTTATTGTGTTCCCGCTGAGCTTTACGAAAAAATGC
TTGATGCGCTGGACGATCAGCAACTGGTTAAATTAGTCCATGAACGGAGCCAACAGCCACTGGTGGATGTTGATCTGGAC
AGCTATTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A7X1BT32